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Basic and Clinical Cancer Research، جلد ۵، شماره ۳، صفحات ۲۳-۲۷
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عنوان انگلیسی Correlation of Homologous Recombination Repair System by Studying a Single-nucleotide Polymorphism in XRCC3 Gene with Initiation and Progression of Colorectal Cancer
چکیده انگلیسی مقاله Background: Colorectal cancer is the third cause of cancer death in western countries. Age, inadequate diet, obesity, inactivity and genetic changes are some of the risk factors of colorectal cancer. Correlation of genetic diversity in homologous recombination repair system with cancer was evaluated in many recent studies. This study was done to investigate the correlation of T241M polymorphism in XRCC3 gene and colorectal cancers. Materials and Methods: In this cross-sectional study, after collecting blood samples and extracting genomic DNA, genotype distribution of the polymorphism was determined by polymerase chain reaction- restriction fragment length polymorphism ( PCR -RFLP) method. Results: A significant correlation was observed between T241M polymorphism and colorectal cancer. Age and family history were also found to be correlated with this cancer. Although no statistically significant relationship has been found between smoking and colon cancer, our findings showed a correlation between smoking and rectum cancer. Furthermore, we observed that the most occurrence of metastatic activity was in the rectum. Conclusion: According to our study, T241M polymorphism in XRCC3 gene from homologous recombination (repair system??) could be a suitable factor for early diagnosis of colorectal cancer, while its co-operation with smoking is also regarded as a risk factor for rectum cancer.
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نویسندگان مقاله مجید متولی باشی | majid motovali bashi
department of genetics, faculty of medical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

جعفر ملکی | jafar maleki
department of biology, faculty of medical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سیمین همتی | simin hemmati
department of oncology and radiotherapy, faculty of medical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

حسن کربکندی | hassan korbekandi
department of genetics and molecular biology, faculty of medical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://bccr.tums.ac.ir/index.php/bccrj/article/view/97
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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