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Acta Medica Iranica، جلد ۵۶، شماره ۷، صفحات ۴۲۹-۴۳۳
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عنوان انگلیسی The pattern of methylation and polymorphism in Interleukin-6 promoter gene are related to the development of Rheumatoid Arthritis?
چکیده انگلیسی مقاله Rheumatoid Arthritis (RA) is a complex disease with higher level of IL-6 . In order to elucidate the alterations related to IL-6 gene in RA, we evaluated the -174 G/C IL-6 gene polymorphism and methylation pattern of its promoter. A total of 120 RA patients and 120 healthy controls were recruited for polymorphism analysis, and 30 individuals of both groups were randomly selected for methylation analysis. The IL-6 gene polymorphism was analyzed by PCR-RFLP and methylation pattern was analyzed by MSP-PCR . Regarding IL-6 gene polymorphism, no significant difference was found between RA patients and controls ( P >0.05). For DNA, two CpG regions of IL-6 promoter gene was analyzed. The first region (−1069, −1061, −1057 and −1001 CpG ) did not show significant differences, whereas the second region (−628, −610, −574 and −491 CpG ) showed a significant hypermethylated status ( P =0.0004) in RA patients as compared with controls.These results, suggest a possible relationship between methylation pattern and the susceptibility to RA in our studied population.
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نویسندگان مقاله | Isaura Isabelle Fonseca Gomes-Silva
Department of Clinical Rheumatology, University of Pernambuco, Rua Arnóbio Marques, 10-Santo Amaro, Recife-PE, Brazil.


| Eliezer Rushansky
Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235-Cidade Universitária, Recife-PE, Brazil.


| Francisco Geraldo Carvalho-Neto
Department of Biology, Rural Federal University of Pernambuco, Rua Manoel de Medeiros-Dois Irmãos, Recife-PE, Brazil.


| Amanda Virginia Batista
University of Pernambuco, Rua Arnóbio Marques, 10 – Santo Amaro, Recife – PE, Brazil.


| Maria Helena Queiroz de Araujo Mariano
Department of Biology, Rural Federal University of Pernambuco, Rua Manoel de Medeiros-Dois Irmãos, Recife-PE, Brazil.


| Paulo Roberto Eleutério de Souza
Department of Biology, Rural Federal University of Pernambuco, Rua Manoel de Medeiros-Dois Irmãos, Recife-PE, Brazil.


| Martín Alejandro Montes
Department of Biology, Rural Federal University of Pernambuco, Rua Manoel de Medeiros-Dois Irmãos, Recife-PE, Brazil.


| Maria Mascena Diniz Maia


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/6344
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-790664.pdf
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