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Basic and Clinical Cancer Research، جلد ۱۰، شماره ۴، صفحات ۰-۰
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عنوان انگلیسی Nanohybrid platform of functionalized graphene oxide for chemo-photothermal therapy
چکیده انگلیسی مقاله Despite the enormous effort has been done for cancer therapy, fabricating targeted drug delivery platform which can effectively eliminate cancer is a challenge. In this study, we have developed a novel platform composed of graphene oxide (GO), poly-l-lysine (PLL), Herceptin (Her) and doxorubicin (DOX) for chemo-photothermal therapy. GO has been prepared using hummers method. The morphology of the prepared carriers has studied using transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The successful conjugation of PLL and Her to the surface of GO has been examined using Fourier-transform infrared spectroscopy (FTIR). DOX loading on GO sheets were characterized using UV-Vis absorption spectra. MTT and live/dead assay has been administrated to study the synergistic chemo-photothermal therapy potential of the carries. Our results have suggested that the novel carrier is a versatile platform for chemo-photothermal therapy application. 
کلیدواژه‌های انگلیسی مقاله Herceptin,ploy (L-lysine),graphene oxide
نویسندگان مقاله | Mohadeseh Hashemi
Protein Research Centre, Shahid Beheshti University, GC, Velenjak, Tehran 1985717443, Iran.


| Meisam Omidi
Faculty of new Science and Engineering, The University of Tehran, Tehran 1439957131, Iran.


| Javad Mohammadi
Protein Research Centre, Shahid Beheshti University, GC, Velenjak, Tehran 1985717443, Iran.


| Mohammad Shalbaf
Protein Research Centre, Shahid Beheshti University, GC, Velenjak, Tehran 1985717443, Iran.


| Javad Shabani Shayeh
Tehran University of Medical Sciences, Cancer Research Center, Tehran, 1419733141, Iran.


| Mohammad Ali Mohagheghi


نشانی اینترنتی http://bccr.tums.ac.ir/index.php/bccrj/article/view/299
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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