این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Medical Laboratory Journal، جلد ۱۰، شماره ۳، صفحات ۳۸-۴۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Detection of Herpes Simplex Virus Infection in Cerebrospinal Fluid
چکیده انگلیسی مقاله ABSTRACT Background and Objective: Herpes simplex encephalitis is a life-threatening consequence of the central nervous system (CNS) infection with Herpes simplex virus (HSV). Although it is a rare disease, mortality rates reach 70% in the absence of therapy and only a minority of individuals can return to normal function. The aim of this study was to determine possible correlation between HSV infection and the incidence of encephalitis in patients with neurological signs. Methods: Overall, 152 CSF samples were tested from patients with neurological signs referred to Mahdieh Clinical Laboratory in Isfahan from 2010 to 2013. After cerebrospinal fluid (CSF) collection, DNA was extracted and real-time polymerase chain reaction (PCR) was performed for HSV detection. Results: Of 152 patients tested, 50 were diagnosed with encephalitis. HSV DNA was present in the CSF of 13 patients with encephalitis. HSV was significantly higher (p< 0.05) in patients with encephalitis, which shows the significance of infection as an etiological factor of this disease. About 60% of the encephalitis cases were in age range of 1-24 months. Conclusion: According to the findings of the present study, Cesarean section is recommended for HSV-positive mothers. A routine real-time PCR test is suggested for HSV detection in patients with encephalitis to avoid unnecessary antiviral treatments.
کلیدواژه‌های انگلیسی مقاله Encephalitis, Herpes simplex virus, Real-Time PCR.
نویسندگان مقاله نوراله رامرودی | nourollah ramroodi
zahedan university of medical science, zahedan, iran


محمد تقی کاردی | mohammad taghi kardi
laboratory of mahdieh, isfehan, iran


مجید بوذری | majid bouzari
faculty of science, university of isfahan, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

مرضیه رضایی | marzieh rezaei
faculty of science, university of isfahan, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

مجید کمیجانی | majid komijani
faculty of science, university of isfahan, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

مهسا یزدی | mahsa yazdi
faculty of science, university of isfahan, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

نشانی اینترنتی http://www.goums.ac.ir/mljgoums/browse.php?a_code=A-10-1-403&slc_lang=fa&sid=fa
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده تخصصی
نوع مقاله منتشر شده تحقیقی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات