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Medical Laboratory Journal، جلد ۱۰، شماره ۱، صفحات ۵۰-۵۵
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عنوان انگلیسی Association of HDL/TG Ratio as an Insulin Resistance Marker with Various Levels of Fasting Blood Glucose
چکیده انگلیسی مقاله ABSTRACT Background and Objective: The association of Triglyceride/High Density Lipoprotein-Cholesterol (TG/HDL-C) ratio with fasting serum insulin, which is an alternative method of insulin resistance (IR) measurement, is well-recognized. Thus, the measurement of TG/HDL-C ratio is useful to determine both IR and dyslipidemia, which itself is a characteristic of individuals with IR. Therefore, this study aimed to investigate the relationship between TG/HDL ratio as an indicator of IR, with different fasting blood glucose levels. Methods: This case-control study was performed on 343 volunteers with no history of diabetes or use of blood glucose-lowering medications and fasting blood sugar (FBS) levels of less than 126 mg/dl. After sampling, the subjects were divided into three groups based on their FBS level. First group included healthy subjects with FBS of less than 100 mg/dl. Second group consisted of subjects with impaired fasting glucose (IFG) and FBS of 110-100 mg/dl and a third group including those with impaired glucose tolerance (IGT) and FBS of 110-125 mg/dl. Results: The amount of TG/HDL-C ratio was 3.8 ± 2.8, 4.0 ± 2.1 and 5.4 ± 3.8 for the healthy group, individuals with IFG and IGT, respectively. The TG/HDL index was significantly different among the tested groups with no significant difference between healthy subjects and subjects with IFG. Moreover, there was a statistically significant difference between the IGT and IFG groups with healthy individuals. Conclusion: Considering the significant increase of the TG/HDL ratio in groups with impaired glucose, using this index can be helpful in evaluation of glycemic disorder.
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نویسندگان مقاله مریم moradibinabaj | maryam moradibinabaj
msc of biochemistry, faculty of medicine


محدثه نامجو | mohadese namjoo
msc of biochemistry


مژگان نجابت | mojgan nejabat
msc of organic chemistry


حمیدرضا جوشقانی | hamidreza joshaghani
department of biochemistry
نشانی اینترنتی http://www.goums.ac.ir/mljgoums/browse.php?a_code=A-10-1-384&slc_lang=fa&sid=fa
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