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International Journal of Organ Transplantation Medicine، جلد ۹، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی One-year Allograft and Patient Survival in Renal Transplant Recipients Receiving Antiplatelet Therapy at the Time of Transplantation
چکیده انگلیسی مقاله Background: Antiplatelet therapy is common in patients on the waiting list for kidney transplantation. Objective: To evaluate the incidence of post-operative bleeding in patients with antiplatelet therapy undergoing kidney transplantation and analyze the impact on the outcome. Methods: We studied all patients with concomitant antiplatelet therapy undergoing kidney transplantation in our center from January 2007 to June 2012. Data were collected by chart review. Univariate and multivariate logistic regression and Cox proportional hazard model were used to identify risk factors for the long-term outcome. Results: Of 744 kidney transplant recipients during the study period, 161 received oral antiplatelet therapy and were included in the study. One-third of the patients demonstrated signs of bleeding, half of which requiring surgical treatment. Coronary artery disease, deceased donor kidney transplantation, and dual antiplatelet medication were independent risk factors for post-operative bleeding. One-year allograft survival was significantly better in the non-bleeding group (91.4% vs 75.9%, p=0.023). Multivariable analysis found that post-operative bleeding, recipient age, and biopsy-proven rejection were independent risk factors for graft survival. Recipient age and biopsy-proven rejection were also identified as independent risk factors for patient survival. Conclusion: This analysis indicated a high risk for post-operative bleeding in renal transplant patients under antiplatelet therapy. The associated negative effect on allograft survival underscored the need to reduce any risk factors for post-operative bleeding.
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نویسندگان مقاله | T Benkö
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University Essen- Duisburg, Germany


| M Gottmann
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University Essen- Duisburg, Germany


| S Radunz
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University Essen- Duisburg, Germany


| A Bienholz
Department of Nephrology, University Hospital Essen, University Essen-Duisburg, Germany


| F H Saner
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University Essen- Duisburg, Germany


| J W Treckmann
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University Essen- Duisburg, Germany


| A Paul
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University Essen- Duisburg, Germany


| D P Hoyer
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University Essen- Duisburg, Germany
نشانی اینترنتی http://www.ijotm.com/ojs/index.php/IJOTM/article/view/508
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/221/article-221-807856.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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