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Iranian Journal of Otorhinolaryngology، جلد ۲۷، شماره ۳، صفحات ۲۰۷-۲۱۱
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عنوان انگلیسی Serum Level of Interleukin-6 in Patients with Oral Tongue Squamous cell Carcinoma
چکیده انگلیسی مقاله Introduction: The clinical outcome of patients with squamous cell carcinoma (SCC) located in the head and neck has remained poor despite ongoing advances in diagnosis and management. Interleukin-6(IL-6) is a multi-functional cytokine that plays an important role in the process of cell differentiation and is increased in several malignancies. The aim of this study was to investigate the serum levels of interleukin-6 in patients with oral tongue SCC. Materials and Methods: In a cross-sectional study, 17 patients with oral tongue SCC were compared with the same number of age- and gender-matched healthy subjects. Serum IL-6 level fluctuation was determined using an immunological technique, before detecting its possible association with the subjects’ age, gender, drinking and smoking history, cancer site, and disease severity. Results: The intensity of serum IL-6 in patients with oral tongue SCC was statistically significantly higher than that in healthy subjects (P< 0.001). Serum IL-6 level was independent of the patients’ age, gender, smoking and drinking history as well as cancer stage. Conclusion: IL-6 is a valuable biomarker in the diagnosis of oral tongue SCC. Its high sensitivity makes prediction of this condition possible, while this biomarker can also be used to screen high-risk patients.
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نویسندگان مقاله علیرضا لطفی | alireza lotfi
hematology and oncology research center, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

غلامرضا bayazian | gholamreza bayazian
department of otorhinolaryngology, hazrat rasool hospital, faculty of medicine, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

شاهین عبدالهی فخیم | shahin abdollahifakhim
department of otorhinolaryngology, imam reza hospital, faculty of medicine, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نیکزاد شهیدی | nikzad shahidi
department of otorhinolaryngology, imam reza hospital, faculty of medicine, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

رسول استخری | rasoul estakhri
department of pathology, imam reza hospital, faculty of medicine, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

علی اصفهانی | ali esfahani
hematology and oncology research center, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

رضوان نوتاش | rezvan notash
department of otorhinolaryngology, imam reza hospital, faculty of medicine, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://ijorl.mums.ac.ir/article_4250.html
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