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Iranian Journal of Otorhinolaryngology، جلد ۲۶، شماره ۳، صفحات ۱۳۵-۱۴۱
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عنوان انگلیسی Effects of Fish Oil Supplementation during the Suckling Period on Auditory Neural Conduction in n-3 Fatty Acid-Deficient Rat Pups
چکیده انگلیسی مقاله Abstract Introduction: Omega 3 fatty acid especially in the form of fish oil, has structural and biological role in the body's various systems especially nervous system. Numerous studies have tried to research about it. Auditory is one of the affected systems. Omega 3 deficiency can have devastating effects on the nervous system and auditory. This study aimed to evaluate neural conduction in n-3 fatty acid-deficient rat pups following the supplementation of fish oil consumption during the suckling period Materials and Methods: In this interventional and experimental study, one sources of omega3 fatty acid (fish oil) were fed to rat pups of n-3 PUFA-deficient dams to compare changes in their auditory neural conduction with that of control and n-3 PUFA-deficient groups, using Auditory Brainstem Response (ABR). The parameters of interest were P1, P3, P4 absolute latency, P1-P3, P1-P4 and P3-P4 IPL , P4/P1 amplitude ratio . The rat pups were given oral fish oil, 5 Ml /g weight for 17 days, between the age of 5 and 21 days. Results There were no significant group differences in P1 and P3 absolute latency (p > 0.05). but the result in P4 was significant(P ≤ 0.05) . The n-3 PUFA deficient +vehicle had the most prolonged (the worst) P1-P4 IPL and P3-P4 IPL compared with control and n-3 PUFA deficient + FO groups. There was no significant difference in P1-P4 IPL and P3-P4 IPL between n-3 PUFA deficient + FO and control groups (p > 0.05).There was a significant effect of diet on P1-P4 IPL and P3-P4 IPL between groups (P ≤ 0.05). Conclusion: The results of present study showed the effect of omega3 deficiency on auditory neural structure during pregnancy and lactation period. Additionally, we observed the reduced devastating effects on neural conduction in n-3 fatty acid-deficient rat pups following the supplementation of fish oil during the suckling period
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نویسندگان مقاله ویدا رحیمی | vida rahimi
department of audiology , school of rehabilitation, tehran university of medical science, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

سعید فراهانی | saeid farahani
department of audiology , school of rehabilitation, tehran university of medical science, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

آتوسا سعیدپور | atoosa saeidpour
department of nutrition, school of nutrition and food technology, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

شهره جلایی | shohre jalaie
department of statistics, school of rehabilitation, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

پروانه مهدی | parvane mahdi
department of audiology , school of rehabilitation, tehran university of medical science, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://ijorl.mums.ac.ir/article_2756.html
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