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Iranian Journal of Otorhinolaryngology، جلد ۲۵، شماره ۴، صفحات ۲۴۵-۲۵۱
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عنوان انگلیسی Giant Keratocystic Odontogenic Tumor: Three Cases and a Literature Review
چکیده انگلیسی مقاله Introduction: A keratocystic odontogenic tumor is a benign intra-bone mass originating from dental lamina or its residue. It represents 2–11% of jaw cysts, and has a slow but aggressive growth. The evaluation of molecular characteristics, immunohistochemistry, and genetic expression currently have no established classification regarding the evolution and pathophysiologic pattern of these lesions. Materials and Methods: This is a clinical retrospective study with a full analysis of patient history regarding physical evaluation, radiologic images, pathology results, and surgical resection. We performed a major literature review concerning current concepts relating to its biological characterization. Results: Three cases of keratocystic odontogenic tumor were identified. Two of the cases were large, with aggressive behavior and significant bone destruction and recurrence, which had been overlooked for more than a decade. The third case had an early diagnosis, and the treatment led to full recovery and complete healing. Conclusion: The keratocystic odontogenic tumor is a benign lesion with slow growth, which lends itself to a more conservative treatment, even in cases of large lesions. A better understanding of these tumors, both at the biological and molecular level, could lead to guidelines for treatment and prognosis of such patients.
کلیدواژه‌های انگلیسی مقاله Keratocystic tumor, Jaw, mandible, odontogenic tumor
نویسندگان مقاله alexandre caixeta guimarães | alexandre caixeta guimarães
department of otorhinolaryngology, university of campinas unicamp , school of medical sciences fcm , são paulo, brazil.


mariana dutra de cassia فریرا سانتوز | mariana dutra de cassia ferreira santos
department of otorhinolaryngology, university of campinas unicamp , school of medical sciences fcm , são paulo, brazil.


guilherme machado de carvalho | guilherme machado de carvalho
department of otorhinolaryngology, university of campinas unicamp , school of medical sciences fcm , são paulo, brazil.


کارلوس takahiro chone | carlos takahiro chone
department of otorhinolaryngology, university of campinas unicamp , school of medical sciences fcm , são paulo, brazil.


leopoldo نظام الدین pfeilsticker | leopoldo nizam pfeilsticker
department of otorhinolaryngology, university of campinas unicamp , school of medical sciences fcm , são paulo, brazil.
نشانی اینترنتی http://ijorl.mums.ac.ir/article_1232.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Case Report
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