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Iranian Journal of Public Health، جلد ۴۷، شماره ۹، صفحات ۱۳۸۷-۱۳۹۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Autism and Probable Prerequisites: Severe and Scheduled Prenatal Stresses at Spotlight
چکیده انگلیسی مقاله Abstract Background: Due to the importance of prenatal maternal stress as environmental factor on autism, the influence of prenatal maternal psychological agitations was assessed in relation with the risk of autism. Methods: In this case-control study, some mothers of autistic children in Isfahan, central Iran, in 2014, were retrospectively compared with control mothers in terms of quantity, quality, andschedule of exposure to 45 stressful events in a 15-month period. In addition, dividing the stressors into two groups of genome-dependent/independent events, their prevalence was separately scrutinized and compared among patient and control families. Results: Although the child’s risk of autism increases significantly with the increase of maternal stress during months 4-7 of pregnancy, the increased stress during months 2-3 of pregnancy can lead to a significant increase in the severity of autism affliction as well as a slight but significant increase in the possibility of LFA in afflicted children ( P < 0.05). The overall prevalence of genome-dependent stressful events among two patient and control groups was significantly higher than that of genome-independent events ( P =0.000), but genome-dependent events led to more stress inpatient families. Conclusion: Although the present study consistent with recent findings in the fields of epigenetics and gene-environment interactions can confirm the role of severe and scheduled prenatal stresses in causing autism, it does not deny the necessity of a perspective and wider study in Isfahan and Iran.
کلیدواژه‌های انگلیسی مقاله Autism, Prenatal stress, Epigenetic
نویسندگان مقاله | Seyyed Mohammad MOUSAVI
Division of Genetics, Dept. of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran


| Elahe KAMALI
Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran


| Fatemeh FATAHI
Dept. of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Genetic and Identification Lab, Legal Medicine Center, Rasht, Iran


| Hadi BABAIE
Dept. of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Medical Genetics Center of Genome, Genome Building, Isfahan, Iran


| Mansoor SALEHI


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/14595
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-827660.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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