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Iranian Journal of Otorhinolaryngology، جلد ۳۰، شماره ۵، صفحات ۲۴۷-۲۵۳
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عنوان انگلیسی The Antiapoptotic Effect of Curcumin in the Fibroblast of the Cochlea in an Ototoxic Rat Model
چکیده انگلیسی مقاله Introduction: This study aimed to show the potency of curcumin as an antiapoptotic agent that decreases the apoptotic index in the cochlea lateral wall in ototoxic rat models.   Materials and Methods: A total of 24 Rattus norvegicus were divided into eight groups: Group 1 (control group), Group 2 (gentamicin (+)), Group 3 (gentamicin + curcumin 20 mg/day), Group 4 (gentamicin + curcumin 40 mg/day), Group 5 (gentamicin + curcumin 20 mg/day for 7 days), Group 6 (gentamicin + curcumin 40 mg/day for 7 days), Group 7 (curcumin 20 mg/day for 3 days + gentamicin), and Group 8 (curcumin 40 mg/day for 3 days + gentamicin). After the division, the rats were terminated in order to measure the apoptotic index using a terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling (TUNEL) assay in the fibroblasts of the cochlea lateral walls. The data were analyzed using analysis of variance (ANOVA), and P< 0.05 was used as the cut-off for statistical significance.   Results: Administration of gentamicin showed significant differences (P< 0.05) in the apoptotic index. Groups undergoing curcumin treatment at a higher dose (200 mg/kg bw) and the prevention groups showed significant differences compared with groups not treated with curcumin   Conclusion: This study concluded that the apoptotic index can be decreased by curcumin and has a preventive benefit toward ototoxic rat models. The administration of curcumin depended on the dose and duration.
کلیدواژه‌های انگلیسی مقاله Apoptosis, Curcumin, Cochlea, Gentamicin, Prevention, Rats
نویسندگان مقاله | Tengku-Siti-Hajar Haryuna
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University Sumatera Utara, Medan 20155, Indonesia.


| Agustinus-Hamonangan-Winston Purba
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University Sumatera Utara, Medan 20155, Indonesia.


| Farhat Farhat
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University Sumatera Utara, Medan 20155, Indonesia.


| Widayat Alviandi
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University Indonesia, Jakarta 10430, Indonesia.
نشانی اینترنتی http://ijorl.mums.ac.ir/article_11407.html
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