این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Cell Journal، جلد ۲۰، شماره ۳، صفحات ۳۵۵-۳۶۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Low Frequency Electrical Stimulation Attenuated The Epileptiform Activity-Induced Changes in Action Potential Features in Hippocampal CA1 Pyramidal Neurons
چکیده انگلیسی مقاله Objective: Electrical low frequency stimulation (LFS) has been introduced as a new therapeutic method to moderate hyperexcitability in epileptic states. It has been shown that seizure occurrence is accompanied with some changes in action potential (AP) features. In this study we tried to investigate the inhibitory action of LFS on the epileptiform activity (EA) induced-changes in AP features in the hippocampal CA1 pyramidal neurons. Materials and methods: In this experimental study, EA was induced in hippocampal slices by increasing the extracellular potassium concentration to 12 mM. LFS (1 Hz) was applied to the Schaffer collaterals at different pulse number (600 and 900) at the beginning of EA. Changes in features of action potential (AP) recorded by whole-cell patch clamp recording were compared using phase plot analysis. Results: Induction of EA depolarized membrane potential, decreased peak amplitude and maximum rise and decay slopes of APs. Administration of 1 Hz LFS at the beginning of EA prevented the above mentioned changes in AP features. This suppressive effect of LFS was dependent to the LFS pulse number so that application of 900 pulses of LFS had stronger recovering effect on the AP features changed during EA compared to 600 pulses of LFS. The constructed phase plots of APs revealed that LFS at 900 pulses significantly decreased the changes in RMP, peak amplitude, maximum rise and decay slopes appeared during EA. Conclusion: Obtained results showed that increasing the number of LFS pulses can magnify its inhibitory effects on the EA-induced changes in AP features.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Zahra Ghasemi


| Nima Naderi


| Amir Shojaei


| Nooshin Ahmadirad


| Mohammad Reza Raoufy


| Javad Mirnajafi-Zadeh


نشانی اینترنتی http://celljournal.org/journal/article/abstract/5443
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/16/article-16-851781.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات