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Cell Journal، جلد ۲۰، شماره ۳، صفحات ۴۲۲-۴۲۶
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عنوان انگلیسی Silymarin Ameliorates Oxidative Stress and Enhances Antioxidant Defense System Capacity in Cadmium-Treated Mice
چکیده انگلیسی مقاله Objective: Cadmium is an environmental pollutant which induces oxidative stress while silymarin as an antioxidant is able to scavenge free radicals. The aim of the present study was to investigate the effect of silymarin on indicators of oxidative stress and the capacity of antioxidant defense system in mice treated with cadmium chloride. Materials and methods: In this experimental study adult mice were divided into four groups: 1. control, 2. cadmium chloride (5 mg/kg b.w., s.c.), 3. silymarin + cadmium chloride and 4. silymarin (100 mg/kg b.w., i.p.). Cadmium chloride was treated for 24 hours and silymarin was used 24 hours before the cadmium. Blood samples were then obtained from the experimental groups and their serums were prepared. To investigate oxidative stress markers in the serum, the amount of malondialdehyde (MDA) and thiol groups (-SH) were evaluated respectively. To measure the total antioxidant power in the serum, Ferric Reducing/ Antioxidant Power (FRAP) method was used. In addition, the activity of enzymes including catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) was assessed to evaluate antioxidant defense system enzymes in the serum. Results: In the cadmium group, the amount of MDA significantly increased as compared to the control group. In silymarin + cadmium group, silymarin significantly ameliorated the level of MDA compared to the cadmium group. In addition, cadmium caused a significant reduction in serum FRAP, the activity of antioxidant defense system enzymes and thiol groups compared to the control. In silymarin + cadmium group, silymarin could significantly reverse the reduction of these indicators compared to the cadmium group. The administration of silymarin alone caused a significant increase in serum FRAP, the activity of antioxidant defense system enzymes and thiol groups compared to the control group. Conclusion: Silymarin as a powerful antioxidant reverses the toxic effect of cadmium on lipid peroxidation, total antioxidant power, the activity of antioxidant defense system enzymes and thiol groups of the serum.
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نویسندگان مقاله | Elham Farjad


| Hamid Reza Momeni


نشانی اینترنتی http://celljournal.org/journal/article/abstract/5355
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