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Cell Journal، جلد ۲۰، شماره ۱، صفحات ۳۱-۴۰
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عنوان انگلیسی Okra (Abelmoscus esculentus) Improved Islets Structure, and Down-Regulated PPARs Gene Expression in Pancreas of High-Fat Diet and Streptozotocin-Induced Diabetic Rats
چکیده انگلیسی مقاله Abstract Objective: Okra (Abelmoscus esculentus) is a tropical vegetable that is rich in carbohydrates, fiber, protein and natural antioxidants. The aim of the present study was to evaluate the effects of Okra powder on pancreatic islets and its action on the expression of PPAR γ and PPAR α genes in pancreas of high fat diet (HFD) induced diabetic rats. Materials and Methods: In this experimental study, diabetes was induced by feeding HFD (60% fat) for 30 days followed by an injection of streptozotocin (STZ) (35 mg/kg). Okra powder (200 mg/kg) was given orally for 30 days after diabetes induction. At the end of experiment, pancreas tissues were removed and stained by H&E and aldehyde fuchsin for determination of the number of the β -cells in pancreatic islets. FBS, TG, cholestrol, HDL, LDL, insulin levels were measured in serum. Moreover, PPAR γ and PPAR α mRNAs expression were measured in pancreas using real time PCR analysis. Results: Okra supplementation significantly decreased the elevated levels of FBG, TC, TG and attenuated HOMA-IR index in diabetic rats. The expression levels of PPARγ and PPAR α genes that were elevated in diabetic rats, attenuated in Okra treated rats (p< 0.05). Furthermore, Okra improved the histological damages of pancreas including vacuolization and decreasing of β-cells mass in diabetic rats. Conclusion: Our findings confirmed the potential anti-hyperglycemic and hypolipidemic effects of Okra. These changes were associated with reduced pancreatic tissue damage. Downregulation of PPARs genes in pancrease of diabetic rats after treatment with Okra, demonstrates that it may improve glucose homeostasis and β-cells impairment in diabetes state through the PPAR -dependent mechanism
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نویسندگان مقاله | Naeem Erfani Majd


| Mohammad Reza Tabandeh


| Ali Shahriari


| Zahra Soliemani


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4819
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