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Cell Journal، جلد ۲۰، شماره ۱، صفحات ۴۱-۴۵
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عنوان انگلیسی Association of ANRIL Expression with Coronary Artery Disease in Type 2 Diabetic Patients
چکیده انگلیسی مقاله Objective: one important antisense Noncoding RNA in the INK4 Locus (ANRIL) is a long RNA transcribed from chromosome 9p21.3, a hot spot region associated with multiple diseases such as coronary artery disease (CAD), type 2 diabetes mellitus (T2DM), and many different types of cancer. It has been shown that its expression is dysregulated in CAD and a variety of other immune-mediated diseases. CAD is a major problem in T2DM patients and cause almost 60% death in these patients worldwide. The aim of the present study was to compare expression level of ANRIL in T2DM patients with and without CAD. Materials and methods: we evaluate the ANRIL expression in peripheral blood mononuclear cells (PBMCs) by Real-time PCR in 64 T2DM patients (33 CAD+ patients and 31 CAD- patients) who were validated by coronary angiography. Results: Expression analysis revealed that ANRIL was up regulated (2.34-Fold; P= 0.012) in CAD+ versus CAD- diabetic patients. Data from Receiver Operating Characteristic (ROC) curve analysis has shown that ANRIL could act as a potential biomarker for detecting CAD in diabetic patients. Conclusion: our data showed that expression level of ANRIL is associate with CAD in diabetic patients and could be considered as a potential peripheral biomarker.
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نویسندگان مقاله | Esameil Rahimi


| Amirhossain Ahmadi


| Mohammad Ali Boroumand


| Bahram Mohammad Soltani


| Mehrdad Behmanesh


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4821
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