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Cell Journal، جلد ۱۹، شماره ۴، صفحات ۵۲۰-۵۲۷
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عنوان انگلیسی Punica granatum L. Fruit Aqueous Extract Suppresses Reactive Oxygen Species-Mediated p53/p65/miR-145 Expressions Followed by Elevated Levels of irs-1 in Alloxan-diabetic Rats
چکیده انگلیسی مقاله Objective: Reactive oxygen species (ROS) is an apoptosis inducer in pancreatic β-cells, and stimulates p53/p65 mediated miR-145 expression. Punica granatum L. (Pomegranate) is an antioxidant fruit that attenuates ROS generation. In this study, the effects of the Pomegranate fruit’s aqueous extract (PGE) on the level of ROS, p53, p65, miR-145 and its target insulin receptor substrate 1 (IRS-1) in Alloxan-diabetic male Wistar rats were examined. Materials and methods: In this experimental study, diabetic rats were administrated with the PGE in different doses and the effects of the PGE polyphenols content were examined through a long-term PGE treatment period model, followed by an evaluation of the plasma and tissue contents of free fatty acids (FFAs), triglyceride (TG) and glycogen compared with diabetic controls (DC) and normal controls (NC). Using Real-time PCR, the modulation of p53, p65, miR-145 and IRS-1 expression levels were investigated. Results: The data showed a noticeable reduction in fasting blood glucose (FBG) and ROS generation compared to DC. Also, a marked decrease in p53, p65, miR-145 expression levels followed by an elevated level of irs-1, which contributed to improving the insulin sensitivity, were observed. Conclusion: The PGE administration downregulates the miR-145 level in Alloxan-diabetic Wistar rats through the suppression of ROS-mediated p53 and p65 overexpression.
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نویسندگان مقاله | Ehsan Gharib


| Shideh Montasser Kouhsari


| Maryam Izad


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4550
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