این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Cell Journal، جلد ۱۹، شماره ۴، صفحات ۵۵۲-۵۵۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Determination of The Properties of Rat Brain Thermostable Protein Complex which Inhibit Cell Proliferation
چکیده انگلیسی مقاله Objective: The cell proliferation is known to be controlled by many networks of regulatory protein. These multiple and complicated mechanisms of control are still being investigated. The aim of the present study is to determine the different properties of adult rat brain thermostable protein complex (TPC) that affects the cell proliferation. Materials and methods: In this experimental study adult (150-170 g) and adolescent (8-10 g) (7, 10, 21, 28 days) white rats, adult pigeon and mice were used. Brain, kidney and liver tissues from all mentioned animals were used as materials. Isolation of brain TPC by alcohol extraction, primary antibodies Ki67 and GAD65/67 for immunohistochemistry, evaluation of transcriptional activity of the tissues and determination of mitotic index were used. Results: The results show that by inhibiting transcription, the brain TPC reversibly decreases cell proliferation. The evidence suggests that TPC is not species-specific, but expresses tissue specificity with regards to terminally differentiated cells. The brain TPC inhibits the mitotic activity of the progenitor cells in dental gyrus of adolescent rats and with the decrease of mitotic index, the number of Ki67 positive cells increases. Simultaneously, the number of GAD65/67-positive cells in the hippocampus decreases by approximately threefold. Conclusion: These results indicate that the brain thermostable protein complex (TPC) causes the reversible suppression of cell proliferation through the inhibition of transcription. Inhibitory effect of the brain TPC leads to an increase the number of cells in the cell cycle, in tissues of adolescent animals.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Diana Dzidziguri


| Irina Modebadze


| Ekaterine Bakuradze


| Giorgi Mosidze


| Manana Berulava


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4835
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/16/article-16-851816.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات