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Cell Journal، جلد ۱۹، شماره ۴، صفحات ۵۷۸-۵۸۴
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عنوان انگلیسی Mouse Bone Marrow-Derived Mast Cells Induce Angiogenesis by Tissue Engineering in Rats: Histological Evidence
چکیده انگلیسی مقاله Objective: Therapeutic angiogenesis is employed to induce vascular network formation and improve functional recovery in ischemia. The aim of this study is to find an appropriate method for recovering local ischemic condition. Materials and methods: Twenty male Wistar rats were arranged into four experimental groups: Ischemia group in which the femoral artery was transected, Phosphate buffer solution group(PBS) in which the femoral artery transected location was immersed with PBS, chitosan(CHIT) group in which the transected location was immersed with 50 µL chitosan solution, and mast cell transplanted group in which the transected location was immersed with a mixture of 50 µL chitosan and 50 µL PBS containing 1×106 mast cells. Results: On day 14 after the surgery, mean number of blood vessels in different size in CHIT/Mast cells group indicated a significant increase compared to other experimental groups (P< 0.05). Conclusion: Our data suggest that mast cells reconstitution could offer a new approach for therapeutic angiogenesis in cases of peripheral arterial diseases.
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نویسندگان مقاله | Ali Karimi


| Rasoul Shahrooz


| Rahim Hobbenaghi


| Rahim Mohammadi


| Esmaeil Mortaz


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4277
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