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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۲۶-۱۲۶
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عنوان انگلیسی Ps-95: Empirical Studies on The Impact of the Application of Vitamin A and C on The Capabalities of The Scaffold Made from Fish Swimming Bag in The presence of Blastema Cells of Rabbit's Ear In vitro
چکیده انگلیسی مقاله Objective: In recent decades regenerative medicine have been widely developed, which in turn led to the most important advances in biomedical research as well as clinical efforts. One of the new challenges is to explore concepts of construction and repair of human tissues by the use of living biological materials through universalizing engineering technologies. In the current study, the use of vitamin A and C in optimizing decellularized scaffold of fish swimming bag has been studied in order to develop the capabilities of scaffolds, including the possibility of a blastema cell adhesion, motility and cell differentiation. Materials and Methods: At first the salmon swim bag was decellularized by the use of Sodium Dodecyl Sulfate. Scaffold impregnation with vitamin A and C was conducted to increase the capabalities of scaffold. Then the tissue and blastema cells in rabbit ear were assembled in decellularized scaffold. At weeks 1, 2 and 4 histologic and histochemichal studies were done in the absence and presence of vitamin A and C to study cell behaviors including motility, proliferation and chondrogenic differentiation or morphological changes of blastema cells. Results: It seems that the strength and vitality of natural decellularized scaffold will increase in the presence of vitamines. And the presence of these compounds will have a positive impact on the morphology and behaviors of the blastema cells including adhesion to the matrix,migration induction,proliferation and differentiation. Conclusion: Efforts to increase the application of biocompatible structures in order to conduct preliminary studies of tissue engineering and studies of the interaction between living cells and ECM scaffold and their impact on cell behavior, may lead into producing and promoting ideal natural scaffolds; or If damaged sites are treated with proper biocompatible bio-active agents such as growth factors or vitamins, which stimulate repairing functional tissue like normal positions, it can be influential in optimizing biological scaffolds. However, performing other special techniques are thought as necessary to understand more accurate mechanisms.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/420
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