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International Journal of Fertility and Sterility، جلد ۱۲، شماره ۱، صفحات ۱-۵
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عنوان انگلیسی Comparison of Cabergoline with Quinagolide in Prevention of Severe Ovarian Hyperstimulation Syndrome among Patients Undergoing Intracytoplasmic Sperm Injection:A randomized trial
چکیده انگلیسی مقاله Objective: The aim of the present study was to compare Quinagolide with Cabergoline in prevention of ovarian hyper stimulation syndrome among high risk women undergoing intra cytoplasmic sperm injection. Materials and methods: Material and Methods: This Randomized clinical trial study was performed from March 2015 to February 2017. One hundred and twenty six women undergoing ICSI and at high risk of developing ovarian hyperstimulation syndrome (>20follicles>12mm developed), were randomized into two groups. The first group received Cabergoline 0.5mg and the second group received Quinagolide 75mg every day for 7 days commencing on the day of GnRH agonist administration. Then ovarian hyperstimulation syndrome symptoms as well as its severity were assessed according to standard definition 3and 6 days after GnRH agonist administration. Ascites was determined by trans-vaginal ultrasound. Other secondary points were number of oocytes, number of embryos and their quality. Quantitative and qualitative data were analyzed using Student's t test, and Chi-square or fisher’s exact test, respectively. A P-value of less than 0.05 was considered statistically significant. Results: Results: The incidence of severe ovarian hyperstimulation syndrome in the Quinagolide group was 3.1% while it was 15.8% in Cabergoline group (p< 0.001). Ascites was less frequent after treatment with Quinagolide as compared with Cabergoline (21.9% versus61.9%) (p= 0.0001). There was no significant statistical deference between the two groups in their mean age, number of oocytes, metaphase I and metaphase II oocytes, and germinal vesicles. There was a significant difference between Cabergoline and Quinagolide groups regarding the embryo number (p=0.037) with Cabergoline group showing a higher number of embryos, but the number of good quality embryo in Quinagolide group was significantly higher than Cabergoline group (p=0.001). Conclusion: Quinagolide seems to be more effective than Cabergoline in prevention of ovarian hyper stimulation syndrome in at risk patients undergoing intra cytoplasmic sperm injection.
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نویسندگان مقاله | Robabeh Taheripanah


| Mahshid Vasef


| Marzieh Zamaniyan


| Anahita Taheripanah


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/5259
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