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International Journal of Fertility and Sterility، جلد ۱۲، شماره ۱، صفحات ۳۷-۴۲
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عنوان انگلیسی Overexpression of Endometrial Estrogen Receptor-Alpha in The Window of Implantation in Women with Unexplained Infertility
چکیده انگلیسی مقاله Objective: Background: Failure in the endometrial receptivity may account for a significant number of infertility cases including unexplained infertility in women. Reduction in the endometrial estrogen receptor-alpha (ER-α) expression during window of implantation may be a critical event that coincides with expression of specific genes and providing a receptive endometrium. The aim of present study was to assess expression of ER-α in the mid-secretory phase in the endometrium of women with unexplained infertility. Materials and methods: Materials and Methods: This case-control study was carried out on randomly selected fertile (n=10) and unexplained infertile (n=16) women. We evaluated the expression of ER-α and glycodelin-A (GdA) through mRNA level measurement with real-time PCR in the endometrium of infertile patients with unexplained infertility and fertile women. Endometrial biopsies were collected during a single menstrual cycle on postovulatory day LH+7 in each subject. Results: Results: Endometrial expression level of ER-α was significantly (p< 0.05) higher in patients with unexplained infertility than fertile control. Significant (p< 0.05) lower level of GdA expression was seen in women with unexplained infertility than fertile controls. No significant but negative correlation found between ER-α and GdA mRNA expression. Conclusion: Conclusion: Our findings demonstrate that reduction in endometrial GdA expression was associated with elevated expression of ER-α in mid-luteal phase. Disruption in endometrial ER-α expression leading to defects in uterine receptivity may contribute to unexplained infertility.
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نویسندگان مقاله | Mehran Dorostghoal


| Hamid-o-allah Ghaffari


| Farideh Marmazi


| Narjes Keikhah


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/5118
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