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International Journal of Fertility and Sterility، جلد ۱۱، شماره ۴، صفحات ۲۴۷-۲۵۲
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عنوان انگلیسی Gene Polymorphism of Matrix Metalloproteinase 9 in Asthenozoospermic Male Subjects
چکیده انگلیسی مقاله Objective: Matrix Metalloproteinase (MMPs) play important roles in the structural and functional properties of reproductive organs. The aim of this study is to determine the prevalence of C-1562T Matrix Metalloproteinase-9 (rs3918242) gene polymorphism in fertile and infertile men. In addition, we aimed to determine the association between C-1562T MMP-9 and G-1575A MMP-2 gene polymorphisms. Materials and methods: A total of 400 subjects, including 200 fertile and 200 infertile men, were recruited for this case-control study. The allele frequencies and genotype distributions of single nucleotide polymorphism in the promoter regions of MMP-9 (C-1562T) were determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The Chi-square (χ2) test was used to assess the distribution of genotype frequencies. Results: No significant differences were found in the genotype distributions or allele frequencies between fertile and infertile men for C-1562T Matrix Metalloproteinase-9 gene polymorphism. The percent of immotile sperm in infertile men with the CC and CT genotypes of C-1562T MMP-9 gene polymorphism were significantly different compared with that of subjects with the TT genotype. The frequency of CC/GA-combined genotypes of C-1562T MMP-9 and G-1575A MMP-2 gene polymorphisms significantly differed in fertile and infertile men (p=0.031). Conclusion: Our results suggest that genetic polymorphisms in matrix metalloproteinases may impact on male fertility.
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نویسندگان مقاله | Sina Mohagheghi


| Iraj Khodadadi


| Manoochehr Karami


| Iraj Amiri


| Heidar Tavilani


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/5038
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/72/article-72-851922.pdf
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