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International Journal of Fertility and Sterility، جلد ۱۱، شماره ۳، صفحات ۱۶۶-۱۷۵
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عنوان انگلیسی Aluminium-Induced Oxidative Stress, Apoptosis and Alterations in Testicular Tissue and Sperm Quality in Wistar Rats: Ameliorative Effects of Curcumin
چکیده انگلیسی مقاله Objective: Reproductive toxicity is a major challenge associated with aluminum (Al) exposure. No studies have evaluated the possible effects of curcumin (CUR) on Al-induced reproductive dysfunction. Therefore, this study investigated the effects of CUR treatment on Al-induced reproductive damage. Materials and methods: In this experimental study, 40 male Wistar rats were allocated to five groups (N=8): to receive no treatment (control), solvent (dimethyl sulfoxide (DMSO) or distilled water), CUR 10 mg/kg body weight (BW), Al chloride 10 mg/kg BW, or both CUR and Al chloride (10 mg/kg BW each alone). Treatments were performed by intraperitoneal injections for 28 days. The left testis was assessed for histopathological analysis as well as the incidence of germ cell apoptosis (by the TUNEL method). One-way analysis of variance (ANOVA) followed by the Tukey’s test was used. P< 0.05 was considered significant. Results: Significant reductions in body and testis weight, plasma testosterone and luteinizing hormone levels, sperm count, motility, morphology, and viability, germinal epithelium thickness, seminiferous tubules diameter, superoxide dismutase activity were observed in rats treated with Al. Moreover, Al exposure caused significant increments in the lumen diameter of tubules, TUNEL-positive cells and malondialdehyde levels compared to the control group. However, in rats receiving both CUR and Al, CUR significantly reversed the adverse effects of Al on testis and sperm quality. No significant differences in follicle-stimulating hormone levels and nuclear diameter of spermatogonia were detected between all groups. Conclusion: It can be concluded that Al causes reproductive dysfunction by creating oxidative damage. CUR, on the other hand, reduces the toxic effects of Al and improves the antioxidant status and sperm quality in male rats.
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نویسندگان مقاله | Ebrahim Cheraghi


| Alireza Golkar


| Kambiz Roshanaei


| Behrang Alani


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/4859
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