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International Journal of Radiation Research، جلد ۱۶، شماره ۳، صفحات ۳۸۳-۳۸۸
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چکیده فارسی مقاله
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عنوان انگلیسی Analysis of microRNAs expression changes in human breast cancer cell lines following exposure to ionizing radiation
چکیده انگلیسی مقاله Background: The expression alterations of specific miRNAs were analysed in response to gamma-irradiation in two breast cancer cell lines MCF-7 and MDA-MB-231 with low and high BCSCs content to design probable strategies for sensitizing breast cancer stem-like cells MDA-MB-231 to radiation. Materials and Methods: The expression levels of hsa-miR-34a, hsa-let-7i and hsa-miR-21 were assessed by QRT-PCR in MCF-7 and MDA-MB-231 breast cancer cells at three time points after gamma irradiation using three different doses. Results: The results showed that the over-expression of hsa-miR-34a in MCF-7 cells was much more significant than MDA-MB-231 cells. Furthermore, there was a considerable over-expression of hsa-miR-21 in MDA-MB-231 cells following exposure to ionizing radiation (IR). The hsa-let-7i expression changes were different, depending on radiation dose, time post irradiation and cell type. Conclusion: According to the results, we may be able to sensitize stem-like MDA-MB-231 breast cancer cells to radiation by increasing miR-34a and decreasing miR-21 expression levels simultaneously.
کلیدواژه‌های انگلیسی مقاله miR-34a, miR-21, let-7i, ionizing radiation, breast cancer.
نویسندگان مقاله | S. Dehghan Kouhestani
Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran


| M. Forouzandeh
Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran


| M. Aghili
Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-1-737&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/42/article-42-857788.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده مطالعه موردی
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