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Iranian Journal of Microbiology، جلد ۳، شماره ۱، صفحات ۲۱-۲۵
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Antimicrobial activity of different Lactobacillus species against multi-drug resistant clinical isolates of Pseudomonas aeruginosa
چکیده انگلیسی مقاله Background : Lactobacilli are the well known friendly bacteria for their probiotic activities against pathogens. The inhibitory activity of different strains of lactobacilli either obtained as commercial products or isolated from human feces was investigated against the clinical isolates of Pseudomonas aeruginosa. The isolates were selected as the most resistant strains when challenged with anti-pseudomonal antibiotics already in clinical practice. Materials and Methods : Both the plate spot test as well as the agar cup method were used for screening of Lactobacillus strains against Pseudomonas aeruginosa. Results : A Lactobacillus acidophilus strain isolated from feces of an Iranian child showed a strong anti-pseudomonal activity (90 percent after 72h incubation) against the multi-drug resistant clinical isolates while a Lactobacillus reuteri strain isolated from a commercial oral product resulted in relatively weak response and a Lactobacillus acidophilus strain isolated from a commercial vaginal product did not show any inhibitory activity. In a kinetic study the lactobacillus sensitive Pseudomonas aeruginosa showed a significant bacteriostatic activity in vitro in the presence of lactobacillus supernatants. Conclusion : Some lactobacilli exhibit significant inhibitory activity against the multidrug resistant clinical isolates of Pseudomonas aeruginosa.
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نویسندگان مقاله h جمالی فر | h jamalifar
departments of drug and food control faculty of pharmacy, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

hr رحیمی | hr rahimi
toxicology faculty of pharmacy, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ناصر | n samadi
departments of drug and food control faculty of pharmacy, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ar شاوردی | ar shaverdi
biotechnology,faculty of pharmacy, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

z شریفیان | z sharifian
department of drug regulatory affairs, iranian food and drug administration, tehran, iran.


حسینی | f hosseini
departments of drug and food control faculty of pharmacy, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

h اصلاحی | h eslahi
departments of drug and food control faculty of pharmacy, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

mr فاضلی | mr fazeli
departments of drug and food control faculty of pharmacy, tehran university of medical sciences, tehran, iran and pharmaceutical quality assurance research center, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/80
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