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Archives of Anesthesiology and Critical Care، جلد ۴، شماره ۴، صفحات ۵۳۸-۵۴۱
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عنوان انگلیسی Comparing the Efficacy of Dexmedetomidine versus Fentanyl and Midazolam During Awake Fiberoptic Intubation
چکیده انگلیسی مقاله Background: Awake oral flexible fiberoptic intubation (AFOI) is used in patients with expected difficult airways. Different drugs have been used for sedation and yet we need to define ideal drug with proper sedation and safety, less changes in hemodynamic stability and less airway compromise. We aimed to compare the efficacy of dexmedetomidine with fentanyl and midazolam during AFOI. Methods: In this randomized clinical trial, 52 patients undergoing elective surgery and candidate for AFOI were randomly allocated to two groups. First group received 1mcg/kg of dexmedetomidine in 10 minutes and then infusion of 0.5 mcg/kg/h and second group received 2 mcg/kg fentanyl and then 1 mg midazolam. Hemodynamic variables, O2 saturation (SpO2) were evaluated before and after sedation and after intubation. Ramsey sedation scale (RSS) and patient’s tolerance were evaluated during bronchoscopy and intubation. Results: Lower heart rate after intubation (p=0.008) and higher SpO2 before sedation (p< 0.001) and after intubation (p=0.02) were observed in dexmedetomidine group compared to fentanyl group. The need for propofol for further sedation was comparable between groups (11.5% vs. 7.7%, respectively; p=0.63). Both groups had comparable RSS and tolerance during intubation. Conclusion: Dexmedetomidine compared to fentanyl and midazolam had comparable sedation with better hemodynamic stability and O2 saturation during AFOI.
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نویسندگان مقاله | Valiollah Hassani
ENT & Head and Neck Research Center, Iran University of Medical Sciences, Tehran, Iran


| Mohammad Farhadi
Department of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran


| Masood Mohseni
Department of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran


| Reza Safaeian
Department of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran


| Nasim Nikoobakht
Department of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran


| Saloomeh Sehat Kashani
Department of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran


| Reza Farahmand Rad
Department of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran


| Shayesteh Pourkand
Department of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran


| Elham Mohebbi


نشانی اینترنتی http://aacc.tums.ac.ir/index.php/aacc/article/view/195
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/371/article-371-863076.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Research Article(s)
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