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Dental Research Journal، جلد ۱۳، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی Effect of local administration of platelet-derived growth factor B on functional recovery of peripheral nerve regeneration: A sciatic nerve transection model
چکیده انگلیسی مقاله Background: Effects of platelet-derived growth factor B (PDGF-B) on peripheral nerve regeneration was studied using a rat sciatic nerve transection model. Materials and Methods: Forty‑five male, white Wistar rats were divided into three experimental groups (n = 15), randomly: Normal control group (NC), silicon group (SIL), and PDGF‑B treated group (SIL/PDGF). In NC group, left sciatic nerve was exposed through a gluteal muscle incision and after homeostasis muscle was sutured. In the SIL group, the left sciatic nerve was exposed the same way and transected proximal to tibio‑peroneal bifurcation leaving a 10‑mm gap. Proximal and distal stumps were each inserted into a silicone conduit and filled with 10 μL phosphate buffered solution. In SIL/PDGF group, the silicon conduit was filled with 10 μL PDGF‑B (0.5 ng/mL). Each group was subdivided into three subgroups of five animals each and were studied 4, 8, 12 weeks after surgery. Results: Behavioral testing, sciatic nerve functional study, gastrocnemius muscle mass, and histomorphometric studies showed earlier regeneration of axons in SIL/PDGF than in SIL group (P < 0.05). Conclusion: Local administration of PDGF‑B combined with silicon grafting could accelerate functional recovery and may have clinical implications for the surgical management of patients after facial nerve transection. Key Words: Conduit, functional recovery, local, nerve repair, platelet‑derived growth factor, sciatic
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نویسندگان مقاله عاطفه گل زاده | atefeh golzadeh


رحیم محمدی | rahim mohammadi


نشانی اینترنتی http://drj.mui.ac.ir/index.php/drj/article/view/1793
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زبان مقاله منتشر شده en
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