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Dental Research Journal، جلد ۱۲، شماره ۲، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی Cytotoxicity evaluation of a copaiba oil-based root canal sealer compared to three commonly used sealers in endodontics
چکیده انگلیسی مقاله large number of clinical cases in endodontics, however, cytotoxicity of such sealers must be tested before their validation as fi lling materials. The aim of this study was to evaluate the cytotoxic effect of a new Copaiba oil-based root canal sealer (Biosealer [BS]) on osteoblast-like Osteo-1 cells. Materials and Methods: The experimental groups were formed according to the culture medium conditioned with the tested sealers, as follows: Control group (CG) (culture medium without conditioning); Sealer 26 (S26) - culture medium + S26; Endofi ll (EF) - culture medium + EF; AH Plus (AHP) - culture medium + AHP; and BS - culture medium + BS (Copaiba oil-based sealer). The conditioned culture medium was placed in contact with 2 × 104 cells cultivated on 60 mm diameter Petri dishes for 24 h. Then, hemocytometer count was performed to evaluate cellular viability, using Trypan Blue assay. The normal distribution of data was tested by the Kolmogorov-Smirnov test and the values obtained for cellular viability were statistically analyzed (1-way ANOVA, Tukey’s test - P < 0.05), with a signifi cance level of 5%. Results: S26, EF and AHP presented decreased cellular viability considerably, with statistical signifi cance compared with CG ( P < 0.05). BS maintained cellular viability similar to CG ( P > 0.05). Conclusion: The Copaiba oil-based root canal sealer presented promising results in terms of cytotoxicity which indicated its usefulness as a root canal sealer. Key Words: Copaiba oil-resin, copaifera genus, cytotoxicity, natural products, root canal sealer
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نویسندگان مقاله آنژلا delfina bittencourt garrido | angela delfina bittencourt garrido


sueli پاتریشیا harumi miyagi de cara | sueli patricia harumi miyagi de cara


marcia martins مارکوس | marcia martins marques


emílio کارلوس sponchiado jr | emílio carlos sponchiado jr


لوکس da fonseca roberti گارسیا | lucas da fonseca roberti garcia


manoel damião de sousa neto | manoel damião de sousa neto


نشانی اینترنتی http://drj.mui.ac.ir/index.php/drj/article/view/1675
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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