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Dental Research Journal، جلد ۱۱، شماره ۲، صفحات ۰-۰
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عنوان انگلیسی Immunohistochemical analysis of B-cell lymphoma -2 in pleomorphic adenoma and mucoepidermoid carcinoma
چکیده انگلیسی مقاله Background: Salivary gland tumors form a major area in the field of oral pathology. B-cell lymphoma -2 (Bcl-2) is an anti-apoptotic gene with up-regulation in various neoplasms. The aim of the present case-control study was to comparatively investigate the expression of Bcl-2 protein in pleomorphic adenoma (PA) and mucoepidermoid carcinoma (MEC) and assess its potential diagnostic role in differentiating these tumors. Materials and Methods: A total of 28 cases (18 specimens of PA [control] and 10 blocks of MEC [case]) were selected for analysis by streptavidin-biotin peroxidase method with antibody against Bcl-2. The percentage of positive cells was calculated from a minimum of 1000 neoplastic cells and H-score was identified (% positive cells × intensity of staining). Data were analyzed using two-way ANOVA, t -test, Spearman, Chi-square and Fisher tests (α = 0.05). Results: bcl-2 expression was shown in 13 cases (71%) of PA and 3 cases (30%) of MEC. In addition, four cases of PA showed strong staining. There was a significant difference between the expression intensity of Bcl-2 in the two tumors ( P = 0.048) according to ANOVA. No correlation was observed between Bcl-2 expression with the size and location of tumors ( P > 0.05). Conclusion: Bcl-2 expression might be used for differentiating these tumors. Bcl-2 protein was overexpressed in PA compared with MEC. Hence, it seems that unlike what was observed in PA, Bcl-2 probably does not participate in the pathogenesis of MEC. Key Words: B-cell lymphoma-2, mucoepidermoid carcinoma, pleomorphic adenoma, salivary gland tumor
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نویسندگان مقاله سعیده عطارباشی | saede atarbashi


مریم الهی | maryam elahi


مهدی خانی | mehdi khani


وحید رخشان | vahid rakhshan


نشانی اینترنتی http://drj.mui.ac.ir/index.php/drj/article/view/1576
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زبان مقاله منتشر شده en
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