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Dental Research Journal، جلد ۱، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی Picibanil (OK‑432) in the treatment of head and neck lymphangiomas in children
چکیده انگلیسی مقاله Background: Picibanil (OK‑432) is a lyophilized mixture of group A Streptococcus pyogenes with antineoplastic activity. Because of its capacity to produce a selective fibrosis of lymphangiomas (LMs), it has been approved by Japanese administration in 1995 for the treatment of LMs. Materials and Methods: We treated 15 children (age range: 6-60 months) affected by head and neck macrocystic LMs with intracystic injections (single dose of 0.2 mL) of Picibanil (1-3 injections). Results: Complete disappearance of the lesion was noticed in eight (53.33%) cases, a marked (>50%) reduction of LMs was found five (33.33%) cases, while a moderate (< 50%) response was recorded in two (13.33%) cases. Picibanil side effects included fever, local inflammation, and transitory increase of blood platelets’ concentration; a single case of anemia was resolved with concentrated red blood cells transfusion. Conclusions: Intracystic injection of Picibanil is an effective and safe treatment for macrocystic LMs in pediatric patients and may represent the treatment of choice in such cases, especially where surgical excision is associated with the risk of functional/cosmetic side effects. Key Words: Children, lymphangiomas, pediatric age, picibanil (OK‑432)
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نویسندگان مقاله النا rebuffini | elena rebuffini


luca zuccarino | luca zuccarino


اما grecchi | emma grecchi


فرانچسکو carinci | francesco carinci


vittorio emanuele merulla | vittorio emanuele merulla


نشانی اینترنتی http://drj.mui.ac.ir/index.php/drj/article/view/1351
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زبان مقاله منتشر شده en
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