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JCR 2016
جستجوی مقالات
سه شنبه 25 آذر 1404
Dental Research Journal
، جلد ۹، شماره ۴، صفحات ۰-۰
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عنوان انگلیسی
Effect of the combination of enamel matrix derivatives and deproteinized bovine bone materials on bone formation in rabbits’ calvarial defects
چکیده انگلیسی مقاله
Background: Various types of materials are used in bone regeneration procedures. The aim of this study was to investigate the use of the enamel matrix derivative (EMD), deproteinized bovine bone mineral (Bio-Oss), and a combination of Bio-Oss plus EMD in the treatment of bone defects created in the rabbits’ calvaria. Materials and Methods: Twenty New Zealand white rabbits were included in this experimental randomized single blind study. Four equal cranial bone defects (3 × 6 × 0.5 mm3) were created in frontal and parietal bone and randomly grafted with Bio-Oss (Group 1), EMD (Group 2), EMD + Bio-Oss (Group 3) and one of them was left unfilled to serve as a control group (Group 4). After 2, 4, 8, and 12 weeks the defects were evaluated by using histological and histomorphometric analysis. Data were analyzed by the Bonferroni test using SPSS 13 statistical software. P value < 0.05 considered as statistically significant level. Results: Bone formation in the EMD + Bio-Oss group after 2 weeks was diminished when statistically compared to the other groups ( P < 0.05). Bone augmentation after 4 weeks from the lowest to the highest were found in groups 1, 3, 2, and 4, respectively, and these differences were statistically significant ( P < 0.05). Using EMD with Bio-Oss increased bone formation in the noncritical defects in the rabbit calvaria during 8 and 12 weeks ( P < 0.05). Conclusions: Boosting of EMD plus Bio-Oss seems to have synergic effect on bone regeneration in bone defects. Key Words: Bone defect, bone grafting, deproteinized bovine bone mineral, enamel matrix derivative
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نویسندگان مقاله
شهریار شهریاری | shahriar shahriari
بهزاد هوشمند | behzad houshmand
حمید رضویان | hamid razavian
صابر خزایی | saber khazaei
فاطمه مشهدی عباس | fatemeh mashhadi abbas
نشانی اینترنتی
http://drj.mui.ac.ir/index.php/drj/article/view/1157
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en
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