این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Dental Research Journal، جلد ۹، شماره ۴، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of IL-8 gene polymorphisms in patients with periodontitis in Hamedan, Iran
چکیده انگلیسی مقاله Background: Many environmental and genetic factors are known as factors that increase the susceptibility to periodontitis. As IL-8 is a chemokine that mediate the inflammatory process in periodontal disease, we decided to evaluate the effect of its polymorphism on chronic and aggressive periodontitis. Materials and Methods: In this cross-sectional study DNA was isolated from the whole blood of 107 periodontitis patients and 199 healthy individuals. All samples were genotyped for the IL-8 polymorphisms using the polymerase chain reaction with sequence specific primers. The distribution of the interleukin-8 genotype and allele frequencies in control and disease groups was analyzed by the Chi-square test and a P -value of < 0.05 was considered statistically significant. Results: The findings revealed that the allele and genotype frequencies of A2767T, T11722T2, and C781T polymorphism of IL-8 gene were not significantly differed between controls and patients. However, there was a significant difference in the genotype frequencies of IL-8 A251T ( P < 0.0001), G396T ( P < 0.0001), and C1633T ( P < 0.0001) gene polymorphism between the patient and the control groups. Additionally, there was a significant difference in the genotype frequencies of C1633T ( P < 0.05) polymorphism of IL-8 gene between the aggressive and chronic periodontitis. Conclusion: IL-8 gene polymorphism may be protective against periodontitis. Key Words: Aggressive periodontitis, chronic periodontitis, genetic polymorphism, interleukin-8
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله بهزاد هوشمند | behzad houshmand


مهرداد حاجیلویی | mehrdad hajilooi


علیرضا رفیعی | alireza rafiei


محسن بیدگلی | mohsen bidgoli


سارا سهیلی فر | sara soheilifar


نشانی اینترنتی http://drj.mui.ac.ir/index.php/drj/article/view/492
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article(s)
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات