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Basic and Clinical Neuroscience، جلد ۹، شماره ۴، صفحات ۱۹۱-۲۰۰
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عنوان انگلیسی The Antinociceptive Effects of Rosuvastatin in Chronic Constriction Injury Model of Male Rats
چکیده انگلیسی مقاله Introduction: According to studies, statins possess analgesics and anti-inflammatory properties. In the present study, we examined the antinociceptive, anti-inflammatory and antioxidative effects of rosuvastatin in an experimental model of Chronic Constriction Injury (CCI). Methods: Our study was conducted on four groups; sham, CCI (the control group), CCI+rosuvastatin (i.p. 5 mg/kg), and CCI+rosuvastatin (i.p. 10 mg/kg). We performed heat hyperalgesia, cold and mechanical allodynia tests on the 3rd, 7th, 14th, and 21st after inducing CCI. Blood samples were collected to measure the serum levels of Tumor Necrosis Factor (TNF)-α, and Interleukin (IL)-6. Rats' spinal cords were also examined to measure tissue concentration of Malondialdehyde (MDA), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GPx) enzymes.  Results: Our findings showed that CCI resulted in significant increase in heat hyperalgesia, cold and mechanical allodynia on the 7th, 14th and 21st day. Rosuvastatin use attenuated the CCI-induced hyperalgesia and allodynia. Rosuvastatin use also resulted in reduction of TNF-α, IL-6, and MDA levels. However, rosuvastatin therapy increased the concentration of SOD and GPx in the CCI+Ros (5 mg/kg) and the CCI+Ros (10 mg/kg) groups compared to the CCI group.  Conclusion: Rosuvastatin attenuated the CCI-induced neuropathic pain and inflammation. Thus, antinociceptive effects of rosuvastatin might be channeled through inhibition of inflammatory biomarkers and antioxidant properties.
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نویسندگان مقاله | Amin Hasanvand
Department of Pharmacology and Toxicology, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.


| Fariba Ahmadizar
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.


| Abolfazl Abbaszadeh
Department of Surgery, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.


| Hossein Amini-Khoei
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.


| Mehdi Goudarzi
Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Amir Abbasnezhad
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.


| Razieh Choghakhori
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-895-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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