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Basic and Clinical Neuroscience، جلد ۹، شماره ۴، صفحات ۲۱۵-۲۲۸
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عنوان انگلیسی Assessing the Effects of Opioids on Pathological Memory by a Computational Model
چکیده انگلیسی مقاله Introduction: Opioids hijack learning and memory formation mechanisms of brain and induce a pathological memory in the hippocampus. This effect is mainly mediated by modifications in glutamatergic system. Speaking more precisely, Opioids presence in a synapse inhibits blockage of N-Methyl-D-Aspartate Receptor (NMDAR) by , enhances conductance of NMDAR and thus, induces false Long-Term Potentiation (LTP).  Methods: Based on experimental observations of different researchers, we developed a mathematical model for a pyramidal neuron of the hippocampus to study this false LTP. The model contains a spine of the pyramidal neuron with NMDAR, α-Amino-3-hydroxy-5-Methyl-4-isoxazole Propionic Acid Receptors (AMPARs), and Voltage-Gated Calcium Channels (VGCCs). The model also describes Calmodulin-dependent protein Kinase II (CaMKII) and AMPAR phosphorylation processes which are assumed to be the indicators of LTP induction in the synapse.  Results: Simulation results indicate that the effect of inhibition of blockage of NMDARs by Mg2+ on the false LTP is not as crucial as the effect of NMDAR's conductance modification by opioids. We also observed that activation of VGCCs has a dominant role in inducing pathological LTP.  Conclusion: Our results confirm that preventing this pathological LTP is possible by three different mechanisms: 1. By decreasing NMDAR's conductance; 2. By attenuating VGCC's mediated current; and 3. By enhancing glutamate clearance rate from the synapse. 
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نویسندگان مقاله | Mehdi Borjkhani
Motor Control and Computational Neuroscience Laboratory, School of Electrical & Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran.


| Fariba Bahrami
Motor Control and Computational Neuroscience Laboratory, School of Electrical & Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran.


| Mahyar Janahmadi
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-1150-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Computational Neuroscience
نوع مقاله منتشر شده Original
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