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International Journal of Fertility and Sterility، جلد ۱۲، شماره ۳، صفحات ۲۴۲-۲۴۸
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عنوان انگلیسی Protective Effects of Matricaria chamomilla Extract on Torsion/ Detorsion-Induced Tissue Damage and Oxidative Stress in Adult Rat Testis
چکیده انگلیسی مقاله Objective: There is some evidence that shows Matricaria chamomile (MC) plays an important role in ischemia-reperfusion. In the present study, a rat model of torsion/detorsion to investigate the effect of hydroalcoholic extract of MC on testis tissue damage was used. In adult rat testis, the oxidative stress (OS) induced by ischemia-reperfusion. Materials and methods: Twenty-eight male Wistar rats were randomly divided into 4 groups; G1, Sham procedure; G2, testicular torsion/detorsion (T/D); G3, testicular torsion/detorsion received 300 mg/kg of MC extracts 30 minutes before detorsion (T/DMC); G4, healthy rats received 300 mg/kg of MC extracts (MC). Also, the reperfusion period was 24 h. After blood sampling, oxidative stress markers, such as Superoxide dismutase (SOD), blood levels of testosterone, and anti-oxidant enzymes, such as Glutathione peroxidase (GPx) assessed by ELISA method and serum activity of malondialdehyde (MDA) were assayed by spectrophotometry. Another assessment was carried out by histomorphometry at 24 h post-procedure. The histological parameters investigated by Johnson's scores (JS) and also the seminiferous tubule diameter (STD) and the height of the germinal epithelium (HE) measured using the linear eyepiece grids on the light microscope. Results: A significant change between sham and other groups was observed in histological parameters. Also, the levels of SOD, GPx, and testosterone hormone were significantly decreased in the sham group while these increased in T/DMC group. In the duration of ischemia, the MDA level increased. Treatment with MC extract decreased the MDA level in G3 and G4 groups. Conclusion: The results of present demonstrated that Matricaria chamomile can be protected the testis tissue damage by suppressing superoxide production after testicular torsion.
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نویسندگان مقاله | Malihe Soltani


| Maryam Moghimian


| Seyes Hosein Abtahi Eivari


| Hamed Shoorei


| Arash Khaki


| Majid Shokoohi


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/5324
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