این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Fertility and Sterility، جلد ۱۲، شماره ۳، صفحات ۲۵۷-۲۶۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Anti-Oxidative and Anti-Apoptotic Effects of Apigenin on Number of Viable and Apoptotic Blastomeres, Zona Pellucida Thickness and Hatching Rate of Mouse Embryos
چکیده انگلیسی مقاله Objective: Apigenin is a plant-derived compound belong to the flavonoids category and has the protective effects on different cells. The aim was to evaluate the effect of apigenin on the number of viable and apoptotic blastomeres, the zona pellucida (ZP) thickness and the hatching rate of preimplantation mouse embryos exposed to H2O2 and actinomycin D. Materials and methods: 420 two-cell embryos were randomly divided into six groups: I. Control, II. Apigenin, III. H2O2, IV. Apigenin + H2O2, V. Actinomycin D, VI. Apigenin + Actinomycin D. The percentage of blastocysts and hatched blastocysts was calculated. The ZP thickness of blastocysts was measured. The number of viable blastomeres was counted by Hoechst and propidium iodide staining and the number of apoptotic blastomeres was counted by TUNEL assay. Results: The results of the number of viable and apoptotic blastomeres, the ZP thickness, and the percentage of blastocysts and hatched blastocysts were significantly more favorable in the apigenin group than the control group (p< 0.05). The results of the apigenin + H2O2 group were significantly more favorable than the H2O2 group (p< 0.05); and the results of the apigenin + actinomycin D group were significantly more favorable than the actinomycin D group (p< 0.05). Conclusion: The results suggest that apigenin may protect the mouse embryos against H2O2 and actinomycin D so that increases the number of viable blastomeres and decreases the number of apoptotic blastomeres, which may cause expanding the blastocysts, thinning of the ZP thickness and increasing the rate of hatching in mouse embryos.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Manouchehr Safari


| Houman Parsaie


| Hamid Reza Sameni


| Mohammad Reza Aldaghi


| Sam Zarbakhsh


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/5392
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/72/article-72-878059.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات