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Molecular Biology Research Communications، جلد ۷، شماره ۳، صفحات ۱۰۷-۱۱۸
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عنوان انگلیسی Computational prediction of miRNAs in Nipah virus genome reveals possible interaction with human genes involved in encephalitis
چکیده انگلیسی مقاله Current re-emergence of Nipah virus (NiV) in India caused 11 deaths so far and many patients were kept in quarantine. A thorough study of previous outbreaks occurred in Malaysia, Bangladesh and India represents cases with high rate of fatality due to acute encephalitis. Our work involves genome analysis of NiV for prediction of miRNAs and their targeted genes in human in order to understand encephalitis origin. Ab-intio program-VMir was used for initial screening of genome, obtained nine pre-miRNAs was analyzed by ViralMir to check for any pseudo pre-miRNAs. Eighteen functional mature miRNAs were extracted from pre-miRNAs by using Mature-Bayes tool, which targets 669 genes in human genome as retrieved by miRDB. Gene ontology terms by PANTHER provide important pathways in which target genes were involved like Axon guidance, T cell activation, and nicotinic acetylcholine receptor signaling. Significant outcome was obtained after NCBI Gene and OMIM database mining and literature search for predicted target genes. TLR3, TJP1, NOTCH2, FHL1, and GRIA3 target genes obtained showed their involvement in host defense, blood brain barrier, neurogenesis, mental retardation and encephalitis. To conclude, we predicted significant genes in human that can be inhibited by miRNAs of NiV and results in etiology of encephalitis.
کلیدواژه‌های انگلیسی مقاله Nipah, miRNA, Encephalitis, Target genes
نویسندگان مقاله Sandeep Saini |
Department of Bioinformatics, G.G.D.S.D. College, Chandigarh, India

Chander Jyoti Thakur |
Department of Bioinformatics, G.G.D.S.D. College, Chandigarh, India

Varinder Kumar |
Department of Bioinformatics, G.G.D.S.D. College, Chandigarh, India

Suchita Tandon |
Department of Bioinformatics, G.G.D.S.D. College, Chandigarh, India

Varuni Bhardwaj |
Department of Bioinformatics, G.G.D.S.D. College, Chandigarh, India

Sonia Maggar |
Department of Bioinformatics, G.G.D.S.D. College, Chandigarh, India

Stanzin Namgyal |
Department of Bioinformatics, G.G.D.S.D. College, Chandigarh, India

Gurpreet Kaur |
Department of Bioinformatics, G.G.D.S.D. College, Chandigarh, India

نشانی اینترنتی http://mbrc.shirazu.ac.ir/article_4886_2f5532ab9d057a24f392e7919dde369b.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/526/article-526-901152.pdf
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زبان مقاله منتشر شده en
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