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Middle East Journal of Cancer، جلد ۶، شماره ۴، صفحات ۲۵۳-۰
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عنوان انگلیسی Serum Adipocytokines (Visfatin and Resistin): New Biomarkers of Breast Carcinogenesis
چکیده انگلیسی مقاله Background: Recent epidemiological studies demonstrate that obesity is associated with an increased risk for breast cancer in women. Increased estrogen levels are suggested as one possible explanation, but this does not fully explain the relationship between obesity and breast cancer. One alternative explanation is secretion by adipocytes of metabolites, hormones and cytokines, collectively known as adipocytokines, which regulate physiological and pathological processes. Among these adipokines are visfatin and resistin. This study investigates whether visfatin or resistin in serum of breast cancer patients can be used as potential diagnostic and prognostic tools for breast cancer, taking into account clinicopathological features and anthropometric parameters. Methods: Blood samples were collected from 70 breast cancer patients (35 obese and 35 non-obese) and 20 healthy females matched for age and body mass index as the control group. Serum visfatin levels were measured by enzyme linked immunosorbent assay and serum resistin levels were measured by radioimmunoassay. Inflammatory status was assessed by measuring C-reactive protein levels by an automated turbidimetric analyzer. Results: We observed highly elevated serum resistin and visfatin levels in breast cancer patients compared to controls, independent of body mass index. Serum resistin and visfatin levels were likely to be associated with increased breast cancer risk and correlated with the inflammatory marker C-reactive protein. Conclusion: Targeting resistin and visfatin inhibition can be an effective therapeutic strategy in breast cancer by downregulating the inflammatory microenvironment in breast tissue. Serum visfatin promises to be a novel biomarker of diagnostic and prognostic value. Larger prospective studies are required to confirm our findings.
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نویسندگان مقاله sanaa a el benhawy | sanaa a el benhawy
radiation science department, medical research institute, alexandria university, alexandria, egypt


نادیا a عبد el moneim | nadia a abd el moneim
cancer management and research department, medical research institute, alexandria university, alexandria, egypt


سمیرا a ebeid | samia a ebeid
applied medical chemistry department, medical research institute, alexandria university, alexandria, egypt
نشانی اینترنتی http://mejc.sums.ac.ir/index.php/mejc/article/view/272
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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