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Middle East Journal of Cancer، جلد ۵، شماره ۳، صفحات ۱۱۹-۰
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عنوان انگلیسی Th1 and Th2 Cytokine Gene Expression in the Peripheral Blood of Breast Cancer Patients Compared to Controls
چکیده انگلیسی مقاله Background : Cytokines produced by different subsets of T cells are the key mediators to adjust the quality of immune responses. Despite evidence of induction of an immune reaction against tumors such as breast cancer, not all responses are protective. In this study we attempt to evaluate the expression profile of several cytokines from the T helper 1 and 2 subsets in blood cells from patients with breast cancer. Methods :We recruited 100 recently diagnosed patients with confirmed pathological reports. Peripheral blood samples were taken and the expression of the transcripts for IL-2, IL-12A, IL-12B, IFN-γ, IL-4, IL-10, IL-13 and IL-13Rα2 were measured by quantitative real time PCR. We correlated the results to clinical findings and compared the results to those from 64 healthy individuals. Results : Among the studied cytokines, we observed a significant increase in the expression of T helper 1 pro-inflammatory cytokines IL-12B, IL-2 and IFN-γ compared to healthy controls. Elevated expression of those cytokines was associated with high stage and/or high grade tumors but there was no association with other clinical determinants. Simultaneously, blood cells showed high expression of IL-10, but not the other studied T helper 2 cytokines. Conclusion : The mixed and complex cytokine profile of T helper 1 and 2 immunity in blood cells may show an immunological imbalance which makes the overall system favor cancer. This may be a potential target for immunotherapy approaches, however more comprehensive results are needed.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله احمد حسینی تشنیزی | ahmad hosseini tashnizi
institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

مجتبی حبیب آگهی | mojtaba habibagahi
department of immunology, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

جعفر مجیدی | jafar majidi
department of immunology, school of medicine, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

محبوبه رزمخواه | mahboobeh razmkhah
institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

عبدالرسول طالعی | abdolrasoul talei
department of surgery, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

عباس قادری | abbas ghaderi
institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

منصوره جابری پور | mansooreh jaberipour
institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://mejc.sums.ac.ir/index.php/mejc/article/view/197
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زبان مقاله منتشر شده en
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