این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Middle East Journal of Cancer، جلد ۵، شماره ۲، صفحات ۹۷-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Estrogen and Progesterone Receptor Expression and its Correlation with Various Clinicopathological Parameters in Ovarian Tumors
چکیده انگلیسی مقاله Background : This study evaluates estrogen and progesterone expressions in patients with ovarian tumors (both benign and malignant) and their correlation with various clinicopathological prognostic parameters. Receptors for estrogen and progesterone are predictive and prognostic markers of endometrial and breast cancers. However, their clinical significance in epithelial ovarian cancer is not clear due to conflicting data from only a few immunohistochemical studies available in the literature. Methods : The present study was conducted on 60 cases of ovarian tumors, 20 benign and 40 malignant. Estrogen and progesterone expressions were studied by immuno- histochemistry and correlated with various clinicopathological parameters such as, menopausal status, histological type, WHO grade and FIGO stage. Results : Out of 20 benign tumors the estrogen receptor was positive in 10 (50%) and progesterone receptor was positive in 14 (70%) tumors. In 40 malignant tumors, the estrogen receptor was positive in 13 (32.5%) and progesterone receptor was positive in 11 (27.5%) cases. There was statistically significant estrogen receptor expression observed in serous tumors (P=0.001). When compared with other clinico- pathological parameters, we noted a significant association between progesterone receptor expression and favorable prognostic parameters such as young age, benign tumors and early FIGO stage. Conclusion : There were variable expressions of the estrogen and progesterone receptors in ovarian tumors. Progesterone receptor expression was associated with favorable prognostic factors that included younger age, benign tumor and low FIGO stage. No such association was observed with estrogen receptor expression.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله shilpa دکتر مانوهر گارگ | shilpa garg
department of pathology and gynecology, pt. b.d sharma post graduate university of medical sciences, rohtak, haryana, india


nisha marwah | nisha marwah
department of pathology and gynecology, pt. b.d sharma post graduate university of medical sciences, rohtak, haryana, india


گلشن chauhan | gulshan chauhan
department of pathology and gynecology, pt. b.d sharma post graduate university of medical sciences, rohtak, haryana, india


sumiti گوپتا | sumiti gupta
department of pathology and gynecology, pt. b.d sharma post graduate university of medical sciences, rohtak, haryana, india


rajiv goyal | rajiv goyal
department of orthopaedics, pt. b.d sharma post graduate university of medical sciences, rohtak, haryana, india


pushpa dahiya | pushpa dahiya
department of pathology and gynecology, pt. b.d sharma post graduate university of medical sciences, rohtak, haryana, india


promil jain | promil jain
department of pathology and gynecology, pt. b.d sharma post graduate university of medical sciences, rohtak, haryana, india


rajiv sen | rajiv sen
department of pathology and gynecology, pt. b.d sharma post graduate university of medical sciences, rohtak, haryana, india
نشانی اینترنتی http://mejc.sums.ac.ir/index.php/mejc/article/view/161
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Brief Communication
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات