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Middle East Journal of Cancer، جلد ۴، شماره ۴، صفحات ۱۵۳-۰
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عنوان انگلیسی Classifying Pediatric Central Nervous System Tumors through near Optimal Feature Selection and Mutual Information: A Single Center Cohort
چکیده انگلیسی مقاله Background : Labeling, gathering mutual information, clustering and classification of central nervous system tumors may assist in predicting not only distinct diagnoses based on tumor-specific features but also prognosis. This study evaluates the epidemi- ological features of central nervous system tumors in children who referred to Mahak’s Pediatric Cancer Treatment and Research Center in Tehran, Iran. Methods : This cohort (convenience sample) study comprised 198 children (≤15 years old) with central nervous system tumors who referred to Mahak's Pediatric Cancer Treatment and Research Center from 2007 to 2010. In addition to the descriptive analyses on epidemiological features and mutual information, we used the Least Squares Support Vector Machines method in MATLAB software to propose a preliminary predictive model of pediatric central nervous system tumor feature-label analysis. Results :Of patients, there were 63.1% males and 36.9% females. Patients' mean±SD age was 6.11±3.65 years. Tumor location was as follows: supra-tentorial (30.3%), infra- tentorial (67.7%) and 2% (spinal). The most frequent tumors registered were: high-grade glioma (supra-tentorial) in 36 (59.99%) patients and medulloblastoma (infra-tentorial) in 65 (48.51%) patients. The most prevalent clinical findings included vomiting, headache and impaired vision. Gender, age, ethnicity, tumor stage and the presence of metastasis were the features predictive of supra-tentorial tumor histology. Conclusion : Our data agreed with previous reports on the epidemiology of central nervous system tumors. Our feature-label analysis has shown how presenting features may partially predict diagnosis. Timely diagnosis and management of central nervous system tumors can lead to decreased disease burden and improved survival. This may be further facilitated through development of partitioning, risk prediction and prognostic models.
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نویسندگان مقاله محمد فرانوش | mohammad faranoush
mahak pediatric cancer treatment and research center mpctrc , tehran, iran


محمد ترابی نامی | mohammad torabi nami
school of advanced medical science and technologies, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

عظیم مهرور | azim mehrvar
mahak pediatric cancer treatment and research center mpctrc , tehran, iran


امیر عباس هدایتی اصل | amir abbas hedayatiasl
mahak pediatric cancer treatment and research center mpctrc , tehran, iran


مریم تشویقی | maryam tashvighi
mahak pediatric cancer treatment and research center mpctrc , tehran, iran


رضا روان پارسا | reza ravan parsa
islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

محمد علی فاضلی | mohammad ali fazeli
mahak pediatric cancer treatment and research center mpctrc , tehran, iran


بهداد ثبوتی | behdad sobuti
mahak pediatric cancer treatment and research center mpctrc , tehran, iran


نرجس مهرور | narjes mehrvar
mahak pediatric cancer treatment and research center mpctrc , tehran, iran


علی جعفرپور | ali jafarpour
mahak pediatric cancer treatment and research center mpctrc , tehran, iran


رخساره زنگویی | rokhsareh zangooei
mahak pediatric cancer treatment and research center mpctrc , tehran, iran


mardawij آل بویه | mardawij alebouyeh
mahak pediatric cancer treatment and research center mpctrc , tehran, iran


محمدرضا ابوالقاسمی | mohammadreza abolghasemi
school of cognitive sciences, institute for research in fundamental sciences ipm , tehran, iran


عبدل حسین وهابی | abdol hossein vahabie
school of cognitive sciences, institute for research in fundamental sciences ipm , tehran, iran


پروانه وثوق | parvaneh vossough
mahak pediatric cancer treatment and research center mpctrc , tehran, iran
نشانی اینترنتی http://mejc.sums.ac.ir/index.php/mejc/article/view/116
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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