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Middle East Journal of Cancer، جلد ۲، شماره ۱، صفحات ۹-۰
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عنوان انگلیسی Eradication of Established Murine Skin Tumors by Cyclic Chemoimmunotherapy with Cyclophosphamide and Effector T Cells
چکیده انگلیسی مقاله Background : Nonmyeloablative chemotherapy followed by adoptive immunotherapy is an attractive strategy for depleting regulatory T cells in the host. However, its efficacy is transient. Here, we aim to investigate whether cyclic chemoim- munotherapy has therapeutic efficacy against cancer. Methods :We examined the efficacy of cyclic chemoimmunotherapy with cyclophos- phamide and adoptively transferred effector T cells against 5-day, established MCA205 murine skin sarcomas. Results : Cyclophosphamide administration followed by adoptive immunotherapy augmented the trafficking of effector T cells into established tumors. Further, multiple cyclophosphamide administrations helped effector T cells to persist at the sites. Chemoimmunotherapy achieved complete tumor regression even with the transfer of a limited number of effector T cells (5×106). Conclusion : Cyclic chemoimmunotherapy, which maintains adoptively transferred T cells by impairing regulatory T cells, is a potentially suitable treatment for established tumors.
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نویسندگان مقاله koki matsuyama | koki matsuyama
division of respiratory medicine, department of homeostatic regulation and development, niigata university, niigata, japan


هیروشی تاناکا | hiroshi tanaka
bioscience medical research center, niigata university medical and dental hospital, niigata, japan


takeshi ota | takeshi ota
division of respiratory medicine, department of homeostatic regulation and development, niigata university, niigata, japan


junko بابا | junko baba
division of respiratory medicine, department of homeostatic regulation and development, niigata university, niigata, japan


takao miyabayashi | takao miyabayashi
division of respiratory medicine, department of homeostatic regulation and development, niigata university, niigata, japan


satoshi watanabe | satoshi watanabe
division of respiratory medicine, department of homeostatic regulation and development, niigata university, niigata, japan


هیروشی kagamu | hiroshi kagamu
division of respiratory medicine, department of homeostatic regulation and development, niigata university, niigata, japan


ichiei narita | ichiei narita
division of respiratory medicine, department of homeostatic regulation and development, niigata university, niigata, japan


koh ناکاتا | koh nakata
bioscience medical research center, niigata university medical and dental hospital, niigata, japan


hirohisa yoshizawa | hirohisa yoshizawa
bioscience medical research center, niigata university medical and dental hospital, niigata, japan
نشانی اینترنتی http://mejc.sums.ac.ir/index.php/mejc/article/view/72
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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