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Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۱۱، صفحات ۱۱۵۵-۱۱۶۰
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چکیده فارسی مقاله
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عنوان انگلیسی Generation of motor neurons from human amygdala-derived neural stem-like cells
چکیده انگلیسی مقاله Objective(s): Among several cell sources, adult human neural stem/progenitor cells (hNS/PCs) have been considered outstanding cells for performing mechanistic studies in in vitro and in vivo models of neurological disorders as well as for potential utility in cell-based therapeutic approaches. Previous studies addressed the isolation and culture of hNS/PCs from human neocortical and hippocampal tissues. However, little data are available on hNS/PCs obtained from the adult human amygdala.Materials and Methods: The present study explored the capacity of the amygdala harvested from resected brain tissues of patients with medically refractory epilepsy to generate neurosphere-like bodies and motor neuron-like cells.Results: Although the proliferation process was slow, a considerable amount of cells was obtained after the 3rd passage. In addition, the cells could generate motor neuron-like cells under appropriate culture conditions. Conclusion: Isolation and culture of these cells enable us to improve our knowledge of the role of the amygdala in some neurological and psychological disorders and provide a novel source for therapeutic cell transplantation.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Sedigheh Ghasemi
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran


| Hadi Aligholi
Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran


| Pir Hossain Koulivand
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran


| Maryam Jafaraian
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran


| Hassan Hosseini Ravandi
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran


| Maryam Khaleghi Ghadiri
Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany


| Ali Gorji
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran|Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany|Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Neurology, Westfälische Wilhelms-Universität Münster, Münster, Germany|Epilepsy Research Center, Westfälische Wilhelms-Universität Münster, Münster, Germany
نشانی اینترنتی http://ijbms.mums.ac.ir/article_11548.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-908796.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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