این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Middle East Journal of Cancer، جلد ۱، شماره ۱، صفحات ۲۷-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Differences in Molecular Pathologic Characteristics of Pancreatic Adenocarcinoma between Egyptian and Moroccan Patients
چکیده انگلیسی مقاله Introduction : Pancreatic cancer has not been well studied, especially in developing countries. Materials and Methods : We studied the variations in genetic mutations in pancreatic adenocarcinoma between Moroccan and Egyptian populations. The molecular pathology of 30 tumors from a large hospital in Casablanca, Morocco were examined and compared with the findings of 44 tumors from the Gharbiah Governate in Egypt. K-ras mutations in codons12 and 13 in addition to p53 mutations in exons 5-8 were evaluated. Results : Overall, differences in the rates of K-ras mutations were not statistically significant (48.00 and 34.09%, respectively); however differences in rates of p53 mutations were statistically significant with p53 mutations more common in Moroccan tumors than in Egyptian tumors (46.67 and 16.28%, respectively). GTmutations of the K-ras gene were most commonly seen Egyptian tumors, whereas GAmutations were the most common type of mutations in Moroccan tumors. Logistic regression analysis showed that a p53 mutation in any exon as well as a p53 mutation in exon 5 predicted the country of residence and those mutations occurred more frequently in Moroccan patients. Conclusion : Our study shows that differences exist within the Arab population in the molecular pathology of both the K-ras and p53 genes. Further studies are necessary to clarify the differences in molecular pathways of pancreatic cancer in the Middle East and to investigate the role of environmental and/or genetic factors related to those pathways.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله سارا robinson | sara robinson
department of epidemiology, university of michigan school of public health, ann arbor, michigan, usa


amr s سلیمان | amr s soliman
department of epidemiology, university of michigan school of public health, ann arbor, michigan, usa


مهدی karkouri | mehdi karkouri
department of pathology, mohammed v university, casablanca, morocco


هدی gad omer | hoda gad omer
department of pathology, tanta cancer center, tanta, egypt


ژول f greenson | joel f greenson
department of pathology, university of michigan school of medicine, ann arbor, michigan, usa
نشانی اینترنتی http://mejc.sums.ac.ir/index.php/mejc/article/view/107
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات