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Journal of Family and Reproductive Health، جلد ۵، شماره ۲، صفحات ۳۵-۳۹
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عنوان انگلیسی A Blinded Study Using Celecoxib for Prevention of Morphine Induced Pruritus in Patients Undergoing Cesarean Section
چکیده انگلیسی مقاله Objective: we aimed to evaluate the efficacy of celecoxib in reducing Intrathecal morphine-induced pruritus in parturient undergoing cesarean section delivery under spinal anesthesia. Materials and methods: In a randomized double-blind placebo controlled study 126 women undergoing elective cesarean section under spinal anesthesia (0.5% bupivacaine 12mg plus 0.2 mg preservativefree morphine )were randomly allocated to receive celecoxib 400 mg or placebo, 2 hours prior to surgery. Severity of pruritus and pain score and frequency of opioid's side effects were recorded. Results: patients receiving celecoxib had significantly lower pruritus incidence and severity at 30 min,2,4 and 8 hours (40% versus 82%), but not at 12 and 24 hours postoperatively. Also there was a reduction in pain score but it was not significant (1.5±0.5 versus 1.9±0.65).Analgesic requirement was similar between two groups. Conclusion: Oral administration of celecoxib significantly reduced Intrathecal morphine-induced pruritus in parturient undergoing cesarean section under spinal anesthesia. There was no significant difference in pain scores and analgesic requirement.
کلیدواژه‌های انگلیسی مقاله Cesarean,Pruritus,Morphine,Celecoxib
نویسندگان مقاله ساغر صمیمی | saghar samimi
anesthesiology department of women amp;amp; 039;s hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فاطمه داوری تنها | fatemeh davari tanha
obs amp;amp; gyn department of women amp;amp; 039;s hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

معصومه ملکیان | masume malekian
obs amp;amp; gyn department of women amp;amp; 039;s hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://jfrh.tums.ac.ir/index.php/jfrh/article/view/119
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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