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Journal of Family and Reproductive Health، جلد ۴، شماره ۴، صفحات ۱۶۵-۱۶۸
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عنوان انگلیسی Effect of Metformin on Diabetes Mellitus Prevention in Pregnant Women with Risk Factors
چکیده انگلیسی مقاله Objective: This study evaluated the efficacy and safety of metformin on prevention of gestational diabetes mellitus in women with high risk of GDM. Materials and methods: Total number of 189 pregnant women aged between 25 to 35, and 10 to 14 weeks pregnancy,admitted to Mirza Koochakkhan Hospital, Tehran in January 2008 - January 2009 entered to this randomized controlled clinical trial. The women had one of the three risk factors; history of GDM, family history of diabetes, or BMI ≥ 30 kg/m 2 , with normal results in the glucose challenge test (GCT) or the glucose tolerance test (GTT). Subjects were randomly split to two groups; 63 women (group A) who received metformin (500 mg, twice a day) and 126 women (group B) did not use metformin. Incidence of gestational diabetes was compared between two groups. Results: The incidence of gestational diabetes was significantly different between two groups (%1.4 in group A, %15.4 in group B) ( p < 0.001). The study also showed that the insulin requirement was significantly different between two groups after developing GDM (group A %3.6, group B %9.5, p =0.001). Conclusion: Using Metformin can effectively reduce the incidence of GDM in pregnant women at risk.
کلیدواژه‌های انگلیسی مقاله Gestational diabetes mellitus,Metformin,Prevention
نویسندگان مقاله شیرین نیرومنش | shirin niroomanesh
department of obstetrics and gynecology, mirza koochackkhan women amp;amp; 039;s hospital, tehran university

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

معصومه معصومه | masoumeh dadashaliha
department of obstetrics and gynecology, mirza koochackkhan women amp;amp; 039;s hospital, tehran university

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

فرحناز احمدی | farahnaz ahmadi
department of obstetrics and gynecology, mirza koochackkhan women amp;amp; 039;s hospital, tehran university

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

فاطمه رحیمی شعرباف | fatemeh rahimi sherbaf
department of obstetrics and gynecology, mirza koochackkhan women amp;amp; 039;s hospital, tehran university

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

فروغ فرقانی | forough forghani
department of obstetrics and gynecology, mirza koochackkhan women amp;amp; 039;s hospital, tehran university

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://jfrh.tums.ac.ir/index.php/jfrh/article/view/109
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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