این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Middle East Journal of Digestive Diseases، جلد ۱۰، شماره ۱، صفحات ۵-۱۷
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عنوان انگلیسی Eradication of Helicobacter Pylori in Iran: A Review
چکیده انگلیسی مقاله Helicobacter pylori ( H. pylori ) infection is one of the most common bacterial infections, affecting almost half of the world’s population. It is associated with peptic ulcer disease, gastric adenocarcinoma, and lymphoma. In Iran, the prevalence of H. pylori infection has been reported to be between 36% and 90% in different geographic regions. Several studies have assessed the efficacy of different therapeutic options for first-line and second-line H. pylori eradication in Iran; however, the results are conflicting. Therefore, we conducted a review to evaluate different studies in order to select the best options and to provide recommendations for H. pylori eradication in Iran. Accordingly, we searched through PubMed to obtain relevant randomized clinical trials published in English language up to June 2017. According to our study, among first-line eradication regimens, bismuth-based furazolidone- or clarithromycin-containing quadruple therapies, hybrid regimen, and concomitant therapy seem to be appropriate options. Also, 10- or 14-day clarithromycin-containing triple therapy can be used if local H. pylori resistance to clarithromycin is known to be less than 15%. For second-line H. pylori eradication, bismuth-based quadruple therapies and 14-day levofloxacin-based triple therapy can be used, provided that antibiotics other than those used in the first-line regimen are used. Third-line H. pylori eradication regimens have not been addressed in Iranian studies. However, most guidelines recommend treatment according to the results of culture and susceptibility testing. Although we limited our investigation to H. pylori eradication regimens in Iran, the results are transferrable to any region as long as the patterns of antibiotic resistance are the same.
کلیدواژه‌های انگلیسی مقاله Helicobacter pylori, Eradication, Iran
نویسندگان مقاله | Hafez Fakheri


| Mehdi Saber Firoozi
Assistant professor of gastroenterology, Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran


| Zohreh Bari


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/1901
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/332/article-332-926859.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Review Article
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