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Iranian Journal of Pediatric Hematology and Oncology، جلد ۸، شماره ۴، صفحات ۲۳۷-۲۴۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
A review of neuroblastoma: prevalence, diagnosis, related genetic factors, and treatment |
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| چکیده انگلیسی مقاله |
Neuroblastoma is considered as the most common solid tumor in children andit is a special types of nervious cells cancer. Neuroblastoma has high potency for metastasis to other organs such as neck, chest, abdomen, or spine. In this narrative review, we assessed prevalence, diagnosis, related factors, and treatment of neuroblastoma based on published articles from 2007 to2017. All published articles in mentioned interval were evaluated and all required data were collected. The collected data were categorized based on determined outlines. According to our findings, neuroblastoma allocated about 10 percent of pediatric cancer to itself. Mortality rate of this cancer is 15% to20% (annualy 15 per million children aged< 9 years). The incidence of this tumor is higher at the first year of life than other years. The highest incidence is observed in children with age range of 0-5 years. This tumor has low prevalence between people aged > 18 years. Important symptoms of neuroblastoma are: fatigue, loss of appetite, fever, bone pain, blemishes of the skin, a lump in the abdomen, neck, or chest, or a painless bluish lump under the skin, weakness, and slackness. The genes involved in this disease include ALK, BARD1, ERBB2, KIF1B, LMO1, MYCN, PHOX2B, 17q gain, loss of 9p, and 3p, loss of 1p 11q. Surgery, chemotherapy (cyclophosphamide, cisplatin, vincristine, doxorubicin, uteroside, and topotecan), radiotherapy, bone marrow transplantation, and transplantation of peripheral blood stem cells are different type of treatment methods for neuroblastoma. The findings of this review also showed that the use of drug delivery system such as lipididic nanostructures, magnetic nanostructures, and other related devices can improve the treatment of neuroblastoma and reduce the side effects induced by different treatments. |
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| کلیدواژههای انگلیسی مقاله |
Neuroblastoma, Genetic Factors, Treatment, Chemotherapy |
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| نویسندگان مقاله |
| Mohammad Javad Forouzani-Moghaddam
Department of Biology, Faculty of Science, Science and Art University, Yazd, Iran
| Parastoo Nabian
Department of Biology, Faculty of Science, Science and Art University, Yazd, Iran
| Arefeh Gholami
Department of Biology, Faculty of Science, Science and Art University, Yazd, Iran
| Neda Dehghanbaghi
Department of Biology, Faculty of Science, Science and Art University, Yazd, Iran
| Mahdieh Azizipanah
Department of Biology, Faculty of Science, Science and Art University, Yazd, Iran
| Kimia Jokar
Department of Biology, Faculty of Science, Science and Art University, Yazd, Iran
| Mahdieh Eslami
Department of Biology, Faculty of Science, Science and Art University, Yazd, Iran
| Zahra Kargarian
Department of Biology, Faculty of Science, Science and Art University, Yazd, Iran
| Motahhareh Tamehri
Department of Biology, Faculty of Science, Science and Art University, Yazd, Iran
| Nazanin Zare
Department of Biology, Faculty of Science, Science and Art University, Yazd, Iran
| Safiehsadat Heydari
Health Information Management Research Center, Kashan University of Medical Sciences, Kashan, Iran
| Marzieh Esmaeili-Karbasi Najafabadi
Department of Biologoy, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
| Maryam Boyerhasani
Department of Biologoy, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
| Hadi Zare-Zardini
Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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| نشانی اینترنتی |
http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-439-1&slc_lang=fa&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/202/article-202-929417.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
پژوهشی |
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