این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Occupational Hygiene، جلد ۱، شماره ۱، صفحات ۲۶-۳۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Development of In Vitro Methods for Toxicity Testing of Workplace Air Contaminants
چکیده انگلیسی مقاله While the OECD test guidelines and mostly animal assays have been used to study the toxic effects of chemicals for many years, very little is known about the potential toxicity of vast majority of inhaled chemicals. Considering large number of chemicals and complex mixtures present in indoor and outdoor air, heavy reliance on animal test methods appear to be not adequate. Continuing scientific developments are needed to improve the process of safety evaluation for the vast number of chemicals and inhaled materials. The aim of this study was to optimise in vitro methods for toxicity testing of airborne contaminants. An integrated approach was designed in which appropriate exposure techniques were developed. A diversified range of in vitro assays using multiple human cell systems were implemented. Direct exposure of cells to airborne contaminants was developed by culturing cells on porous membranes in conjunction with a horizontal diffusion chamber system. Dose-response curves were generated allowing the measurement of toxicity endpoints. Toxicity ranking of test chemicals, based on obtained IC 50 (50% inhibitory concentration) values, in different human cells and in vitro assays were determined. Airborne IC 50 values were calculated for selected volatile organic compounds (xylene; 5350 ± 328 ppm > toluene; 10500 ± 527 ppm) and gaseous contaminants (NO 2 ; 11 ± 3.54 ppm > SO 2 ; 48 ± 2.83 ppm > and NH 3 ; 199 ± 1.41 ppm). Results of this research indicate the significant potential of in vitro methods as an advanced technology for toxicity assessment of airborne contaminants.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله شهناز باکند | shahnaz bakand
department of occupational health, school of public health, iran university of medical sciences.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

آماندا hayes | amanda hayes
chemical safety and applied toxicology csat laboratories, school of risk and safety sciences, the


کریس winder | chris winder
chemical safety and applied toxicology csat laboratories, school of risk and safety sciences, the university of new south wales, unsw sydney, 2052
نشانی اینترنتی http://ijoh.tums.ac.ir/index.php/ijoh/article/view/5
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات