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Iranian Journal of Pathology، جلد ۱۰، شماره ۴، صفحات ۲۸۱-۲۸۹
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عنوان انگلیسی Renal Tumours in Adults with Correlation between Fuhrman Grading and Proliferative Marker
چکیده انگلیسی مقاله Background: Definite data regarding the incidence and distribution of renal tumours in eastern India is not known. For better management, as it is essential to identify patients with poor prognosis, prognostic factors like stage, nuclear grade and their relationship to molecular markers are also unclear in this region. The purpose of our study was to assess the spectrum of adult renal tumours with respect to age and sex and to correlate Fuhrman nuclear grading with Ki-67 labeling index in a tertiary care hospital in eastern India. Methods: All adult patients with kidney tumour referred to our hospital who were preoperatively diagnosed and undergone surgical resection were included. Distribution of histological subtypes of kidney tumours according to age and sex were done by Hematoxylin and Eosin stain. Fuhrman grading, performed by ocular morphometry and derivation of Ki-67 labeling index (LI), were done in malignant cases only. Correlation of Fuhrman grading and KI-67 LI were done individually. Results: Among total 36 cases, 3 were benign and 33 were malignant. Among the malignant cases: Fifteen, twelve, four and two cases were of Fuhrman grade I, II, III, IV with mean Ki67 labeling index of 6.5, 18.2,44 and 76 respectively. Statistical correlation between mean Ki-67 LI and Fuhrman grading revealed significant correlation between Grade I and II, II and III and combined Grade I,II and III,IV tumours. Conclusion: Malignant Kidney tumours, especially, grade I RCC were commonest tumour. Fuhrman grading correlated well with Ki-67 labeling index. A 2-tier system for grading is proposed for better correlation with proliferation.
کلیدواژه‌های انگلیسی مقاله Kidney tumours,Adults,RCC,Ki-67,Fuhrman grading
نویسندگان مقاله sabuj غنا mukhopadhyay | ghana mukhopadhyay
department of pathology, burdwan medical college, burdwan, west bengal,india

krishnendu mukherjee |
department of immunohematology and blood transfusion, medical college. kolkata

آسیم kr manna | kr manna
department of pathology, ipgmer, kolkata

نشانی اینترنتی http://ijp.iranpath.org/article_13215_55c6d51a6741e7b585f0acd80e963ae9.pdf
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